000171033 001__ 171033
000171033 005__ 20260505142649.0
000171033 0247_ $$2doi$$a10.1016/j.cmi.2026.03.021
000171033 0248_ $$2sideral$$a149119
000171033 037__ $$aART-2026-149119
000171033 041__ $$aeng
000171033 100__ $$aGupta, Nitin
000171033 245__ $$aNipah virus in South Asia: from emergence to enduring preparedness' challenges
000171033 260__ $$c2026
000171033 5203_ $$aBackground. Nipah virus (NiV) is a highly lethal zoonotic virus that has caused sporadic but severe outbreaks in South and Southeast Asia since its emergence in 1998. Despite the relatively small size of most outbreaks, NiV poses a substantial public health challenge due to its high case fatality rate.
Objectives. To examine the evolving epidemiology, clinical features, virological insights, and preparedness challenges associated with NiV infection in South Asia.
Sources. We conducted a narrative review synthesising epidemiological, clinical, and public health data from national surveillance systems, WHO Disease Outbreak News reports, and published outbreak investigations.
Content. We describe the shift from pig-amplified transmission observed in Malaysia to bat-driven spillover and human-to-human transmission, particularly within household and hospital settings, as characterised by recent outbreaks in Bangladesh and eastern India, and specifically review Kerala's experience since 2018. Particular attention is given to the re-emergence of NiV in West Bengal in early 2026, involving a limited cluster of infections among healthcare workers that was rapidly contained but remains epidemiologically important given the region's prior history of nosocomial spread. We discuss persistent challenges in early diagnosis, access to high-containment laboratory testing, and clinical management, alongside emerging roles for mobile Biosafety Level 3 laboratories and point-of-care diagnostics.
Implications. Overall, the South Asian experience underscores that NiV represents a persistent zoonotic threat rather than an episodic emergence, necessitating sustained preparedness, pathogen-agnostic clinical vigilance, and proportionate risk communication to mitigate future outbreaks. Sustained preparedness, rather than episodic alarm, must guide future responses.
000171033 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000171033 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000171033 700__ $$aGkrania-Klotsas, Effrossyni
000171033 700__ $$aDrexler, Jan Felix
000171033 700__ $$aBanerjee, Sayantan
000171033 700__ $$aTsiodras, Sotirios
000171033 700__ $$aRay, Yogiraj
000171033 700__ $$aJokelainen, Pikka
000171033 700__ $$aMora-Rillo, Marta
000171033 700__ $$aBarac, Aleksandra
000171033 700__ $$aGrobusch, Martin P.
000171033 700__ $$aLescure, F-Xavier
000171033 700__ $$aBarac, Aleksandra
000171033 700__ $$aBulescu, Casandra
000171033 700__ $$aDrexler, Jan Felix
000171033 700__ $$aGkrania-Klotsas, Effrossyni
000171033 700__ $$aGrobusch, Martin P.
000171033 700__ $$aGupta, Nitin
000171033 700__ $$aJokelainen, Pikka
000171033 700__ $$aLescure, F-Xavier
000171033 700__ $$aMora-Rillo, Marta
000171033 700__ $$aPellejero-Sagastizabal, Galadriel
000171033 700__ $$aPaño-Pardo, José Ramón
000171033 700__ $$aTsiodras, Sotirios
000171033 773__ $$pClin. microbiol. infect.$$tClinical Microbiology and Infection$$x1198-743X
000171033 8564_ $$s1291236$$uhttps://zaguan.unizar.es/record/171033/files/texto_completo.pdf$$yVersión publicada
000171033 8564_ $$s2744123$$uhttps://zaguan.unizar.es/record/171033/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000171033 909CO $$ooai:zaguan.unizar.es:171033$$particulos$$pdriver
000171033 951__ $$a2026-05-05-13:36:10
000171033 980__ $$aARTICLE