171134 20260515163944.0 doi 10.1007/s00198-015-3159-1 sideral 92302 ART-2015-92302 eng Matute-Llorente, A. Universidad de Zaragoza (orcid)0000-0001-8500-1667 Effect of whole body vibration training on bone mineral density and bone quality in adolescents with Down syndrome: a randomized controlled trial 2015 Summary Adolescents with Down syndrome (DS) have poorer bone health than their peers without DS. Twenty-five adolescents with DS were randomly assigned to whole-body vibration training (WBV) or control groups. The results indicate that a 20-week WBV might be useful to improve subtotal bone mineral content and density in adolescents with DS. Introduction This study aims to determine the effects of 20 weeks of whole body vibration training (WBV) on bone mineral content (BMC), density (BMD), and structure variables in adolescents with Down syndrome (DS). Methods This randomized controlled trial of 25 adolescents (12–18 years) with DS (8 females) generated 2 non-equal groups, WBV group (n = 11) and CON group (n = 14). Using an efficacy analysis, the primary outcomes were BMC and BMD by dual-energy X-ray absorptiometry and the secondary were bone structure variables by peripheral quantitative computed tomography. A synchronous vibration platform (PowerPlate®) was used (3/week, 10 repetitions (30–60 s) 1-min rest, frequency of 25–30 Hz, and peak-to-peak displacement of 2 mm (peak acceleration 2.5–3.6 g)). Results WBV group improved whole body BMC 2.8 %, 95 % CI [3.5, 2.1], subtotal area, BMC, and BMD by 2.8, 4.8, and 2 %, respectively, 95 % confidence intervals (CIs) [3.4, 2.1], [6.5, 3.1], and [2.8, 1.1], respectively (all, p < 0.05), showing group by time interactions in BMC and BMD (both p < 0.05). Lumbar spine BMC and BMD also increased in the WBV group by 6.6 and 3.3 % both p < 0.05, 95 % CIs [8.6, 4.7], and [4.9, 1.7], respectively. Regarding bone structure, WBV group showed improvements in tibial BMC at 4 % (2.9 %, 95 % CI [3.0, 2.8]) and in volumetric BMD (vBMD), cortical vBMD, and cortical thickness at 66 % of the radius (by 7.0, 2.4, and 10.9 %; 95 % CIs [7.4, 6.7], [2.6, 2.3], and [12.4, 9.3], respectively) (all, p < 0.05). Conclusions A 20-week WBV, with this protocol, might be useful to improve subtotal BMC and BMD in adolescents with DS. info:eu-repo/grantAgreement/ES/MEC/AP-2012-02854 info:eu-repo/grantAgreement/ES/MICINN/DEP2009-09183 info:eu-repo/semantics/closedAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 3.445 2015 ENDOCRINOLOGY & METABOLISM 45 / 131 = 0.344 2015 Q2 T2 1.48 2015 Medicine (miscellaneous) 2015 Q1 Endocrinology, Diabetes and Metabolism 2015 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion González-Agüero, A. Universidad de Zaragoza (orcid)0000-0002-1132-5906 Gómez-Cabello, A. (orcid)0000-0001-6492-2512 Olmedillas, H. Vicente-Rodríguez, G. Universidad de Zaragoza (orcid)0000-0002-4303-4097 Casajús, J. A. Universidad de Zaragoza (orcid)0000-0002-7215-6931 1006 245 Universidad de Zaragoza Dpto. Fisiatría y Enfermería Área Educación Física y Depor. 26, 10 (2015), 2449-2459 Osteoporos. int. OSTEOPOROSIS INTERNATIONAL 0937-941X 584824 http://zaguan.unizar.es/record/171134/files/texto_completo.pdf Versión publicada 2021877 http://zaguan.unizar.es/record/171134/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:171134 articulos driver 2026-05-15-14:53:28 ARTICLE