171160 20260515163945.0 doi 10.1113/expphysiol.2010.052860 sideral 85609 ART-2011-85609 eng Prats, C Intracellular compartmentalization of skeletal muscle glycogen metabolism and insulin signalling 2011 The interest in skeletal muscle metabolism and insulin signalling has increased exponentially in recent years as a consequence of their role in the development of type 2 diabetes mellitus. Despite this, the exact mechanisms involved in the regulation of skeletal muscle glycogen metabolism and insulin signalling transduction remain elusive. We believe that one of the reasons is that the role of intracellular compartmentalization as a regulator of metabolic pathways and signalling transduction has been rather ignored. This paper briefly reviews the literature to discuss the role of intracellular compartmentalization in the regulation of skeletal muscle glycogen metabolism and insulin signalling. As a result, a hypothetical regulatory mechanism is proposed by which cells could direct glycogen resynthesis towards different pools of glycogen particles depending on the metabolic needs. Furthermore, we discuss the role of skeletal muscle transverse tubules as potential modulators of tissue insulin responsiveness. Access copy available to the general public Unrestricted info:eu-repo/semantics/openAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 3.211 2011 PHYSIOLOGY 24 / 78 = 0.308 2011 Q2 T1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Gómez-Cabello, A Universidad de Zaragoza (orcid)0000-0001-6492-2512 Hansen, AV 1006 245 Universidad de Zaragoza Dpto. Fisiatría y Enfermería Área Educación Física y Depor. 96, 4 (2011), 385-390 Exp. physiol. EXPERIMENTAL PHYSIOLOGY 0958-0670 444445 http://zaguan.unizar.es/record/171160/files/texto_completo.pdf Versión publicada 2680629 http://zaguan.unizar.es/record/171160/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:171160 articulos driver 2026-05-15-14:54:07 ARTICLE