000171192 001__ 171192
000171192 005__ 20260515163945.0
000171192 0247_ $$2doi$$a10.1038/s42003-026-09637-4
000171192 0248_ $$2sideral$$a149264
000171192 037__ $$aART-2026-149264
000171192 041__ $$aeng
000171192 100__ $$aBlazquez-Romero, Maria del Valle$$uUniversidad de Zaragoza
000171192 245__ $$aPeriodic confined cell migration drives partially reversible chromatin reorganization in cancer cell lines
000171192 260__ $$c2026
000171192 5060_ $$aAccess copy available to the general public$$fUnrestricted
000171192 5203_ $$aCells throughout physiological and pathological contexts are exposed to a broad spectrum of mechanical stimuli, triggering extensive nuclear deformation and chromatin remodeling. These mechanical cues drive the cell to dynamically adapt through coordinated structural, epigenetic, and biochemical mechanisms to withstand mechanical stress while protecting genomic integrity. However, whether such cellular adaptations are reversible or result in persistent alterations remains unresolved. In cancer metastasis, addressing this issue is critical: confined migration through narrow pores prompts chromatin condensation with heterochromatin enrichment, yet cancer cells must preserve their oncogenic potential while preparing for future deformations. Therefore, the ability of these cells to reconcile reversible chromatin remodeling and mechanical memory could be key to metastatic resilience. Here, using a custom-designed microfluidic device to monitor single-cell chromatin reorganization, we show confined migration induces partially-reversible chromatin condensation: total highly-condensed chromatin content is recovered after deformation, but the distribution of condensed chromatin clusters remains altered. Our findings highlight this duality of chromatin condensation as both a short-term adaptive response and a mechanical memory strategy, which could potentially contribute to address cancer invasiveness.
000171192 536__ $$9info:eu-repo/grantAgreement/ES/DGA/E36-23R-FENOL$$9info:eu-repo/grantAgreement/ES/DGA/LMP21-21$$9info:eu-repo/grantAgreement/ES/DGA/T50-23R$$9info:eu-repo/grantAgreement/ES/MCIU/PID2022-139803NB-I00$$9info:eu-repo/grantAgreement/ES/MICINN PID2023-147067NB-I00$$9info:eu-repo/grantAgreement/ES/MICINN/PID2023-147734NB-I00$$9info:eu-repo/grantAgreement/ES/MICINN PRE2021-100456$$9info:eu-repo/grantAgreement/ES/MICINN PRE2023-001133$$9info:eu-repo/grantAgreement/ES/MINECO/PID2024-155426OB-I00
000171192 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
000171192 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000171192 700__ $$aMendivil-Carboni, Marco
000171192 700__ $$aSarasquete-Martinez, Maria$$uUniversidad de Zaragoza
000171192 700__ $$aSainz-Agost, Alejandro$$uUniversidad de Zaragoza
000171192 700__ $$0(orcid)0000-0002-9551-624X$$aFalo, Fernando$$uUniversidad de Zaragoza
000171192 700__ $$0(orcid)0000-0002-9361-4794$$aDe Corato, Marco$$uUniversidad de Zaragoza
000171192 700__ $$0(orcid)0000-0002-1878-8997$$aGomez-Benito, Maria Jose$$uUniversidad de Zaragoza
000171192 7102_ $$15001$$2600$$aUniversidad de Zaragoza$$bDpto. Ciencia Tecnol.Mater.Fl.$$cÁrea Mecánica de Fluidos
000171192 7102_ $$15008$$2800$$aUniversidad de Zaragoza$$bDpto. Ingeniería Electrón.Com.$$cÁrea Teoría Señal y Comunicac.
000171192 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est.
000171192 7102_ $$12003$$2395$$aUniversidad de Zaragoza$$bDpto. Física Materia Condensa.$$cÁrea Física Materia Condensada
000171192 773__ $$g9, 1 (2026), [17 pp.]$$tCommunications Biology$$x2399-3642
000171192 8564_ $$s5252665$$uhttps://zaguan.unizar.es/record/171192/files/texto_completo.pdf$$yVersión publicada
000171192 8564_ $$s2779866$$uhttps://zaguan.unizar.es/record/171192/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000171192 909CO $$ooai:zaguan.unizar.es:171192$$particulos$$pdriver
000171192 951__ $$a2026-05-15-14:54:47
000171192 980__ $$aARTICLE