000171256 001__ 171256
000171256 005__ 20260515163946.0
000171256 0247_ $$2doi$$a10.1177/1352458510397414
000171256 0248_ $$2sideral$$a149301
000171256 037__ $$aART-2011-149301
000171256 041__ $$aeng
000171256 100__ $$aGarcia-Martin, E
000171256 245__ $$aEffect of optic neuritis on progressive axonal damage in multiple sclerosis patients
000171256 260__ $$c2011
000171256 5203_ $$aObjective:
The objective of this research was to study the effect of optic neuritis (ON) on axonal damage in multiple sclerosis (MS) patients. Specifically, we compared changes over 2 years in the retinal nerve fibre layer (RNFL) between affected and contralateral eyes in MS patients with a prior history of ON.
Methods:
Thirty-four patients with one unilateral definitive episode of ON were included and underwent a complete ophthalmic examination, optical coherence tomography (OCT), scanning laser polarimetry, visual evoked potentials (VEP) and pattern electroretinogram (pERG). All patients were re-evaluated at 12 and 24 months. Parameters were compared between ON-affected and contralateral eyes in an initial exploration and over the course of the follow-up. Correlations between parameter changes were analysed.
Results:
RNFL thickness and functional parameters showed more affection in ON eyes (p ≤ 0.05), but changes in measurements during the study were similar between both groups of eyes.
Conclusions:
Progressive axonal loss can be detected in the optic nerve, but ON is not a risk factor for increased chronic damage in MS patients without ophthalmic relapses. Loss of the RNFL is caused by progressive degeneration associated with the disease.
000171256 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000171256 590__ $$a4.255$$b2011
000171256 591__ $$aCLINICAL NEUROLOGY$$b27 / 192 = 0.141$$c2011$$dQ1$$eT1
000171256 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000171256 700__ $$0(orcid)0000-0002-1777-0349$$aPueyo, V$$uUniversidad de Zaragoza
000171256 700__ $$aAra, JR
000171256 700__ $$aAlmarcegui, C
000171256 700__ $$aMartin, J
000171256 700__ $$aPablo, L
000171256 700__ $$aDolz, I
000171256 700__ $$aSancho, E
000171256 700__ $$aFernandez, FJ
000171256 7102_ $$11004$$2646$$aUniversidad de Zaragoza$$bDpto. Cirugía,Ginecol.Obstetr.$$cÁrea Oftalmología
000171256 773__ $$g17, 7 (2011), 830-837$$pMult. scler.$$tMULTIPLE SCLEROSIS$$x1352-4585
000171256 8564_ $$s168199$$uhttps://zaguan.unizar.es/record/171256/files/texto_completo.pdf$$yVersión publicada
000171256 8564_ $$s2127724$$uhttps://zaguan.unizar.es/record/171256/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000171256 909CO $$ooai:zaguan.unizar.es:171256$$particulos$$pdriver
000171256 951__ $$a2026-05-15-14:56:05
000171256 980__ $$aARTICLE