171256 20260515163946.0 doi 10.1177/1352458510397414 sideral 149301 ART-2011-149301 eng Garcia-Martin, E Effect of optic neuritis on progressive axonal damage in multiple sclerosis patients 2011 Objective: The objective of this research was to study the effect of optic neuritis (ON) on axonal damage in multiple sclerosis (MS) patients. Specifically, we compared changes over 2 years in the retinal nerve fibre layer (RNFL) between affected and contralateral eyes in MS patients with a prior history of ON. Methods: Thirty-four patients with one unilateral definitive episode of ON were included and underwent a complete ophthalmic examination, optical coherence tomography (OCT), scanning laser polarimetry, visual evoked potentials (VEP) and pattern electroretinogram (pERG). All patients were re-evaluated at 12 and 24 months. Parameters were compared between ON-affected and contralateral eyes in an initial exploration and over the course of the follow-up. Correlations between parameter changes were analysed. Results: RNFL thickness and functional parameters showed more affection in ON eyes (p ≤ 0.05), but changes in measurements during the study were similar between both groups of eyes. Conclusions: Progressive axonal loss can be detected in the optic nerve, but ON is not a risk factor for increased chronic damage in MS patients without ophthalmic relapses. Loss of the RNFL is caused by progressive degeneration associated with the disease. info:eu-repo/semantics/closedAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 4.255 2011 CLINICAL NEUROLOGY 27 / 192 = 0.141 2011 Q1 T1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Pueyo, V Universidad de Zaragoza (orcid)0000-0002-1777-0349 Ara, JR Almarcegui, C Martin, J Pablo, L Dolz, I Sancho, E Fernandez, FJ 1004 646 Universidad de Zaragoza Dpto. Cirugía,Ginecol.Obstetr. Área Oftalmología 17, 7 (2011), 830-837 Mult. scler. MULTIPLE SCLEROSIS 1352-4585 168199 http://zaguan.unizar.es/record/171256/files/texto_completo.pdf Versión publicada 2127724 http://zaguan.unizar.es/record/171256/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:171256 articulos driver 2026-05-15-14:56:05 ARTICLE