000171646 001__ 171646
000171646 005__ 20260527123126.0
000171646 0247_ $$2doi$$a10.1371/journal.pone.0333649
000171646 0248_ $$2sideral$$a149363
000171646 037__ $$aART-2026-149363
000171646 041__ $$aeng
000171646 100__ $$aBurgos-Bragado, José Manuel
000171646 245__ $$aAsynchronous telerehabilitation in prehabilitation and postoperative recovery for colorectal cancer: A protocol for a randomized controlled trial
000171646 260__ $$c2026
000171646 5060_ $$aAccess copy available to the general public$$fUnrestricted
000171646 5203_ $$aIntroduction
Colorectal cancer (CRC) is a leading global malignancy, and surgery is frequently followed by complications, functional decline, and reduced quality of life. Multimodal prehabilitation and rehabilitation can improve physical recovery and psychosocial outcomes, but uptake is often limited by logistical and mobility barriers. Asynchronous telerehabilitation offers a flexible, patient-centered, and scalable approach; however, its effectiveness across the perioperative CRC pathway has not been rigorously evaluated. This trial will evaluate a multimodal asynchronous program delivered in prehabilitation and postoperative phases, against a booklet-based usual-care approach reflecting the pre-existing perioperative pathway in the study setting before trial initiation.
Methods
This single-blind, parallel-group randomized controlled trial will compare an asynchronous multimodal telerehabilitation program with a booklet-based usual-care program in adults scheduled for elective CRC resection. Fifty-six participants will be randomized 1:1 to the telerehabilitation group (HEFORA platform) or the usual-care control group. The intervention includes a 2-week prehabilitation phase and a 4-week postoperative rehabilitation phase. Assessments will be performed at five time points: baseline (pre-prehabilitation), post-prehabilitation (pre-surgery), post-surgery (pre-rehabilitation), post-rehabilitation, and 3-month
Outcomes
The primary outcome is functional capacity, measured by the Six-Minute Walk Test distance. Secondary outcomes include muscle strength, body composition, pulmonary function, physical activity, sleep quality, psychosocial variables, health-related quality of life, treatment expectancy, usability, satisfaction, and adherence. Analyses will follow the intention-to-treat principle using longitudinal models and sensitivity analyses for missing data and adherence. Conclusions: This study will provide evidence on the role of asynchronous telerehabilitation in perioperative colorectal cancer care. Positive results could inform clinical guidelines, promote wider adoption of digital rehabilitation strategies, and support a more accessible, patient-centered, and cost-effective approach to oncologic recovery.
000171646 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B61-23D
000171646 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000171646 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000171646 700__ $$aJiménez-Sánchez, Carolina
000171646 700__ $$aBrandín de la Cruz, Natalia
000171646 700__ $$aCarpallo-Porcar, Beatriz
000171646 700__ $$aRoux-Ethève, Lilian Le
000171646 700__ $$0(orcid)0000-0001-7004-4664$$aBlas-Laina, Juan Luis
000171646 700__ $$aAlamillo-Salas, Jorge
000171646 700__ $$aGracia Gimeno, Paola
000171646 700__ $$0(orcid)0000-0002-1674-7788$$aCalvo, Sandra$$uUniversidad de Zaragoza
000171646 7102_ $$11006$$2413$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Fisioterapia
000171646 773__ $$g21, 4 (2026), e0333649 [23 pp.]$$pPLoS One$$tPLoS ONE$$x1932-6203
000171646 8564_ $$s1149037$$uhttps://zaguan.unizar.es/record/171646/files/texto_completo.pdf$$yVersión publicada
000171646 8564_ $$s2118776$$uhttps://zaguan.unizar.es/record/171646/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000171646 909CO $$ooai:zaguan.unizar.es:171646$$particulos$$pdriver
000171646 951__ $$a2026-05-27-11:25:42
000171646 980__ $$aARTICLE