000171659 001__ 171659
000171659 005__ 20260527123127.0
000171659 0247_ $$2doi$$a10.1016/j.rvsc.2026.106263
000171659 0248_ $$2sideral$$a149368
000171659 037__ $$aART-2026-149368
000171659 041__ $$aeng
000171659 100__ $$0(orcid)0000-0002-1934-5397$$aLoste, Araceli$$uUniversidad de Zaragoza
000171659 245__ $$aMetabolic and urinary profiles in normal-weight, overweight and obese dogs: clinical response to an individualised weight loss programme
000171659 260__ $$c2026
000171659 5060_ $$aAccess copy available to the general public$$fUnrestricted
000171659 5203_ $$aCanine overweight and obesity mirrors human trends, emphasizing a One Health perspective. This prospective study evaluated haematological, biochemical and urinary parameters, alongside systolic blood pressure (SBP), in client-owned dogs: normal-weight (NW, n = 10), overweight (OW, n = 10) and obese (OB, n = 10). Overweight and obese dogs followed a 150-day caloric restriction programme (high-protein, high-fibre, low-energy) with biweekly veterinary follow-up.
At baseline, triglycerides were significantly higher in OB (126.6 mg/dL) compared to controls (57.6 mg/dL; p < 0.05). While serum total protein, globulin, C-reactive protein and calcium were significantly higher in OB (p < 0.05), mean values remained within clinical reference intervals. Baseline SBP in OB (191.3 mmHg) was significantly higher (p < 0.05) than in NW. Post-intervention, mean weight loss reached 9.43% (OW) and 9.83% (OB). Success in achieving ideal body condition was higher in OW (87.5%) than OB (30%) (p < 0.05). In obese group, hypertriglyceridaemia normalised (126.6 to 78.4 mg/dl; p < 0.01) and SBP significantly decreased (191.3 to 174 mmHg; p < 0.05). Programme success strongly correlated with improved physical activity (p < 0.05) and quality of life (p < 0.01).
These findings confirm that canine obesity induces metabolic and inflammatory dysregulation, even in apparently healthy dogs. Results demonstrate that structured nutritional programmes can significantly mitigate these alterations, although certain inflammatory markers, like C-reactive protein, may not fully reach control levels within the study timeframe. Notably, clinically relevant improvements occurred before achieving ideal body condition, highlighting the efficacy of early intervention and sustained veterinary-owner engagement in weight management strategies.
000171659 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
000171659 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000171659 700__ $$0(orcid)0000-0002-0680-9957$$aBorobia, Marta$$uUniversidad de Zaragoza
000171659 700__ $$0(orcid)0000-0001-5560-3771$$aGarcía, Alberto$$uUniversidad de Zaragoza
000171659 700__ $$aEscobar, Lucía
000171659 700__ $$0(orcid)0000-0002-0540-734X$$aNavarro, Laura$$uUniversidad de Zaragoza
000171659 7102_ $$11003$$2027$$aUniversidad de Zaragoza$$bDpto. Anatom.Histolog.Humanas$$cArea Anatom.Embriol.Humana
000171659 7102_ $$11009$$2617$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Medicina y Cirugía Animal
000171659 773__ $$g208 (2026), 106263 [17 pp.]$$pRes. Vet. Sci.$$tRESEARCH IN VETERINARY SCIENCE$$x0034-5288
000171659 8564_ $$s2259369$$uhttps://zaguan.unizar.es/record/171659/files/texto_completo.pdf$$yVersión publicada
000171659 8564_ $$s2385913$$uhttps://zaguan.unizar.es/record/171659/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000171659 909CO $$ooai:zaguan.unizar.es:171659$$particulos$$pdriver
000171659 951__ $$a2026-05-27-11:25:58
000171659 980__ $$aARTICLE