000171749 001__ 171749
000171749 005__ 20260603114407.0
000171749 0247_ $$2doi$$a10.1002/adfm.202600080
000171749 0248_ $$2sideral$$a149494
000171749 037__ $$aART-2026-149494
000171749 041__ $$aeng
000171749 100__ $$aBenaicha-Fernández, Amina
000171749 245__ $$aIntrinsic Photoactive Star ZnPc–Poly(glutamate) Nanoplatforms for Multimodal Glioblastoma Therapy and Brain‐Targeted Delivery
000171749 260__ $$c2026
000171749 5060_ $$aAccess copy available to the general public$$fUnrestricted
000171749 5203_ $$aABSTRACT
The design of polymeric systems with intrinsically integrated imaging and responsive functionalities represents a promising strategy to address the complexity of aggressive tumors such as glioblastoma multiforme (GBM). We report a class of star‐shaped zinc phthalocyanine–poly(L‐glutamic acid) (ZnPc‐PGA) nanocarriers in which the photoactive ZnPc core serves as a macroinitiator for the N‐carboxyanhydride ring‐opening polymerization, enabling control over chain length, architecture, and stoichiometry. ZnPc‐PGA nanocarriers exhibited near‐infrared absorption, enabling their implementation as imaging agents and photosensitizers for photodynamic therapy. Physicochemical characterization of ZnPc‐PGA nanocarriers revealed chain‐length‐ and concentration‐dependent supramolecular assembly. ZnPc‐PGA nanocarriers demonstrated lysosomal uptake/light‐activated cytotoxicity in GBM cells, while evaluation in the GBM‐on‐a‐chip platform confirmed oxygen‐dependent therapeutic outcomes. Proteomic profiling revealed a fibrinogen‐, cytoskeletal‐, and olfactory protein‐enriched corona, providing insight into potential biointerface interactions. Post‐polymerization conjugation of ZnPc‐PGA nanocarriers with paclitaxel facilitated multimodal therapy with enhanced efficacy in GBM cells, while integrating ZnPc‐PGA nanocarriers into a hyaluronic acid‐based hydrogel enabled intranasal delivery and resulted in brain accumulation. Overall, ZnPc‐PGA represents a modular nanoplatform and underscores the role of polymer architecture in dictating behavior in complex biological environments, with potential applicability in the design of multifunctional systems for challenging diseases such as GBM.
000171749 536__ $$9info:eu-repo/grantAgreement/ES/AEI/PID2021-126051OB-C41$$9info:eu-repo/grantAgreement/ES/DGA/T62-230R$$9info:eu-repo/grantAgreement/ES/MCIU/PID2023-152459OB-I00$$9info:eu-repo/grantAgreement/ES/MICIU/PRTR-C17.I1$$9info:eu-repo/grantAgreement/ES/MINECO-RTICC-ISCIII-CIBERONC/CB22-12-0048
000171749 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
000171749 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000171749 700__ $$0(orcid)0000-0001-7232-7588$$aRandelovic, Teodora
000171749 700__ $$aArmiñán, Ana
000171749 700__ $$0(orcid)0000-0002-6873-5244$$aSebastián, Víctor$$uUniversidad de Zaragoza
000171749 700__ $$aFuentes, Manuel
000171749 700__ $$aHuck-Iriart, Cristián
000171749 700__ $$aMasiá, Esther
000171749 700__ $$aCarrascosa-Marco, Paula
000171749 700__ $$aJuanes-Velasco, Pablo
000171749 700__ $$aÐordevic, Snežana
000171749 700__ $$aBayona, Clara
000171749 700__ $$0(orcid)0000-0003-2410-5678$$aOchoa, Ignacio$$uUniversidad de Zaragoza
000171749 700__ $$aMedel, Maria
000171749 700__ $$aConejos-Sánchez, Inmaculada
000171749 700__ $$aVicent, María J.
000171749 7102_ $$11003$$2443$$aUniversidad de Zaragoza$$bDpto. Anatom.Histolog.Humanas$$cArea Histología
000171749 7102_ $$15005$$2555$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Ingeniería Química
000171749 773__ $$g(2026), e00080 [23 pp.]$$pAdv. funct. mater.$$tAdvanced Functional Materials$$x1616-301X
000171749 8564_ $$s5012225$$uhttps://zaguan.unizar.es/record/171749/files/texto_completo.pdf$$yVersión publicada
000171749 8564_ $$s2450917$$uhttps://zaguan.unizar.es/record/171749/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000171749 909CO $$ooai:zaguan.unizar.es:171749$$particulos$$pdriver
000171749 951__ $$a2026-06-03-11:04:33
000171749 980__ $$aARTICLE