000032155 001__ 32155 000032155 005__ 20210121082856.0 000032155 0247_ $$2doi$$a10.1056/NEJMc1501657 000032155 0248_ $$2sideral$$a90382 000032155 037__ $$aART-2015-90382 000032155 041__ $$aeng 000032155 100__ $$0(orcid)0000-0002-7284-8890$$aGazulla, J.$$uUniversidad de Zaragoza 000032155 245__ $$aMultiple-system atrophy 000032155 260__ $$c2015 000032155 5060_ $$aAccess copy available to the general public$$fUnrestricted 000032155 5203_ $$aFanciulli and Wenning's review (Jan. 15 issue) on multiple-system atrophy is comprehensive and up to date. In it, the authors state that the open-label administration of gabapentin could ameliorate cerebellar symptoms in single cases of this disease. However, the cited reference describes a noticeable improvement in gait in one patient who received a diagnosis of olivopontocerebellar atrophy (OPCA) after a single dose of 400 mg of gabapentin and alleviation of dysarthria and oscillopsia in another patient with OPCA during long-term therapy with gabapentin. These patients could not have received a diagnosis of multiple-system atrophy, since neither had features of autonomic dysfunction. In contrast, gabapentin was found to cause generalized weakness and to worsen gait and dysarthria in three patients with multiple-system atrophy, forcing withdrawal of the drug... 000032155 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/ 000032155 590__ $$a59.558$$b2015 000032155 591__ $$aMEDICINE, GENERAL & INTERNAL$$b1 / 155 = 0.006$$c2015$$dQ1$$eT1 000032155 592__ $$a16.591$$b2015 000032155 593__ $$aMedicine (miscellaneous)$$c2015$$dQ1 000032155 655_4 $$ainfo:eu-repo/semantics/other$$vinfo:eu-repo/semantics/publishedVersion 000032155 700__ $$aBerciano, J. 000032155 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina 000032155 773__ $$g372, 14 (2015), 1374$$pN. Engl. j. med.$$tNEW ENGLAND JOURNAL OF MEDICINE$$x0028-4793 000032155 8564_ $$s286309$$uhttps://zaguan.unizar.es/record/32155/files/texto_completo.pdf$$yVersión publicada 000032155 8564_ $$s99614$$uhttps://zaguan.unizar.es/record/32155/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000032155 909CO $$ooai:zaguan.unizar.es:32155$$particulos$$pdriver 000032155 951__ $$a2021-01-21-08:13:27 000032155 980__ $$aARTICLE