32158 20180112134735.0 doi 10.1007/s10237-013-0508-x sideral 86472 ART-2014-86472 eng Borau, C. A time-dependent phenomenological model for cell mechano-sensing 2014 Access copy available to the general public Unrestricted Adherent cells normally apply forces as a generic means of sensing and responding to the mechanical nature of their surrounding environment. How these forces vary as a function of the extracellular rigidity is critical to understanding the regulatory functions that drive important phenomena such as wound healing or muscle contraction. In recognition of this fact, experiments have been conducted to understand cell rigidity-sensing properties under known conditions of the extracellular environment, opening new possibilities for modeling this active behaviour. In this work, we provide a physics-based constitutive model taking into account the main structural components of the cell to reproduce its most significant contractile properties such as the traction forces exerted as a function of time and the extracellular stiffness. This model shows how the interplay between the time-dependent response of the acto-myosin contractile system and the elastic response of the cell components determine the mechano-sensing behaviour of single cells. info:eu-repo/grantAgreement/ES/MINECO/DPI2009-14115-CO3-01 info:eu-repo/grantAgreement/ES/MINECO/BES-2010-029927-FPI info:eu-repo/grantAgreement/EUR/FP7/ERC2012-StG-306751 info:eu-repo/semantics/openAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 3.145 2014 ENGINEERING, BIOMEDICAL 17 / 76 = 0.224 2014 Q1 T1 BIOPHYSICS 26 / 73 = 0.356 2014 Q2 T2 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Kamm, R.D. (orcid)0000-0002-9864-7683 García-Aznar, J.M. Universidad de Zaragoza 5004 605 Universidad de Zaragoza Departamento de Ingeniería Mecánica Mec. de Medios Contínuos y Teor. de Estructuras 13, 2 (2014), 451-462 Biomech. model. mechanobiol. Biomechanics and Modeling in Mechanobiology 1617-7959 1063769 http://zaguan.unizar.es/record/32158/files/texto_completo.pdf Postprint 89971 http://zaguan.unizar.es/record/32158/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:32158 articulos driver 2018-01-12-13:46:45 ARTICLE