32187 20210121082904.0 doi 10.1242/dmm.021774 sideral 92187 ART-2015-92187 eng (orcid)0000-0002-4379-1100 Llobet, Laura Universidad de Zaragoza Xenobiotics that affect oxidative phosphorylation alter differentiation of human adipose-derived stem cells at concentrations that are found in human blood 2015 Access copy available to the general public Unrestricted Adipogenesis is accompanied by differentiation of adipose tissuederived stem cells to adipocytes. As part of this differentiation, biogenesis of the oxidative phosphorylation system occurs. Many chemical compounds used in medicine, agriculture or other human activities affect oxidative phosphorylation function. Therefore, these xenobiotics could alter adipogenesis. We have analyzed the effects on adipocyte differentiation of some xenobiotics that act on the oxidative phosphorylation system. The tested concentrations have been previously reported in human blood. Our results show that pharmaceutical drugs that decrease mitochondrial DNA replication, such as nucleoside reverse transcriptase inhibitors, or inhibitors of mitochondrial protein synthesis, such as ribosomal antibiotics, diminish adipocyte differentiation and leptin secretion. By contrast, the environmental chemical pollutant tributyltin chloride, which inhibits the ATP synthase of the oxidative phosphorylation system, can promote adipocyte differentiation and leptin secretion, leading to obesity and metabolic syndrome as postulated by the obesogen hypothesis. info:eu-repo/grantAgreement/ES/FIS/PI14-00005 info:eu-repo/grantAgreement/ES/FIS/PI14-00070 info:eu-repo/grantAgreement/ES/IACS/PIPAMER-09-01 info:eu-repo/grantAgreement/ES/IACS/PIPAMER-10-010 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 4.316 2015 PATHOLOGY 10 / 79 = 0.127 2015 Q1 T1 CELL BIOLOGY 59 / 187 = 0.316 2015 Q2 T1 2.712 2015 Biochemistry, Genetics and Molecular Biology (miscellaneous) 2015 Q1 Neuroscience (miscellaneous) 2015 Q1 Medicine (miscellaneous) 2015 Q1 Immunology and Microbiology (miscellaneous) 2015 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion (orcid)0000-0002-7243-1737 Toivonen, Janne M Universidad de Zaragoza (orcid)0000-0003-1770-6299 Montoya, Julio Universidad de Zaragoza (orcid)0000-0002-0269-7337 Ruiz-Pesini, Eduardo Universidad de Zaragoza (orcid)0000-0002-3217-1424 López-Gallardo, Ester Universidad de Zaragoza 1001 420 Universidad de Zaragoza Dpto. Anatom.,Embri.Genét.Ani. Área Genética 1003 443 Universidad de Zaragoza Dpto. Anatom.Histolog.Humanas Area Histología 1002 060 Universidad de Zaragoza Dpto. Bioq.Biolog.Mol. Celular Área Bioquímica y Biolog.Mole. 8 (2015), 1441-1455 Disease Models & Mechanisms Disease Models & Mechanisms 1754-8403 1680793 http://zaguan.unizar.es/record/32187/files/texto_completo.pdf Versión publicada 137300 http://zaguan.unizar.es/record/32187/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:32187 articulos driver 2021-01-21-08:17:30 ARTICLE