000032195 001__ 32195
000032195 005__ 20210121082859.0
000032195 0247_ $$2doi$$a10.1371/journal.pone.0136632
000032195 0248_ $$2sideral$$a92324
000032195 037__ $$aART-2015-92324
000032195 041__ $$aeng
000032195 100__ $$aRossetti, L.
000032195 245__ $$aBlindness and glaucoma: A multicenter data review from 7 academic eye clinics
000032195 260__ $$c2015
000032195 5060_ $$aAccess copy available to the general public$$fUnrestricted
000032195 5203_ $$aPurpose To evaluate frequency, conversion rate, and risk factors for blindness in glaucoma patients treated in European Universities. Methods This multicenter retrospective study included 2402 consecutive patients with glaucoma in at least one eye. Medical charts were inspected and patients were divided into those blind and the remainder (''controls''). Blindness was defined as visual acuity-0.05 and/or visual field loss to less than 10°. Results Unilateral and bilateral blindness were respectively 11.0% and 1.6%at the beginning, and 15.5%and 3.6% at the end of the observation period (7.5±5.5 years, range:1-25 years)//conversion to blindness (at least unilateral) was 1.1%/year. 134 eyes (97 patients) developed blindness by POAG during the study. At the first access to study centre, they had mean deviation (MD) of -17.1±8.3 dB and treated intraocular pressure (IOP) of 17.1±6.6 mmHg. During follow-up the IOP decreased by 14%in these eyes but MD deteriorated by 1.1±3.5 dB/year, which was 5-fold higher than controls (0.2±1.6 dB/year). In a multivariate model, the best predictors for blindness by glaucoma were initial MD (p<0.001), initial IOP (p<0.001), older age at the beginning of follow-up (p<0.001), whereas final IOP was found to be protective (p<0.05). Conclusions In this series of patients, blindness occurred in about 20%. Blindness by glaucoma had 2 characteristics: late diagnosis and/or late referral, and progression of the disease despite in most cases IOP was within the range of normality and target IOP was achieved//it could be predicted by high initial MD, high initial IOP, and old age.
000032195 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000032195 590__ $$a3.057$$b2015
000032195 591__ $$aMULTIDISCIPLINARY SCIENCES$$b11 / 62 = 0.177$$c2015$$dQ1$$eT1
000032195 592__ $$a1.427$$b2015
000032195 593__ $$aAgricultural and Biological Sciences (miscellaneous)$$c2015$$dQ1
000032195 593__ $$aMedicine (miscellaneous)$$c2015$$dQ1
000032195 593__ $$aBiochemistry, Genetics and Molecular Biology (miscellaneous)$$c2015$$dQ1
000032195 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000032195 700__ $$aDigiuni, M.
000032195 700__ $$aGiovanni, M.
000032195 700__ $$aCentofanti, M.
000032195 700__ $$aFea, A.M.
000032195 700__ $$aIester, M.
000032195 700__ $$aFrezzotti, P.
000032195 700__ $$aFigus, M.
000032195 700__ $$0(orcid)0000-0002-2914-2593$$aFerreras, A.$$uUniversidad de Zaragoza
000032195 700__ $$aOddone, F.
000032195 700__ $$aTanga, L.
000032195 700__ $$aRolle, T.
000032195 700__ $$aBattaglino, V.
000032195 700__ $$aPosarelli, C.
000032195 700__ $$aMotolese, I.
000032195 700__ $$aMittica, P.
000032195 700__ $$aBagaglia, S.A.
000032195 700__ $$aMenicacci, C.
000032195 700__ $$aDe Cilla'', S.
000032195 700__ $$aAutelitano, A.
000032195 700__ $$aFogagnolo, P.
000032195 7102_ $$11004$$2646$$aUniversidad de Zaragoza$$bDpto. Cirugía,Ginecol.Obstetr.$$cÁrea Oftalmología
000032195 773__ $$g10, 8 (2015), 0136632 [12 p.]$$pPLoS One$$tPloS one$$x1932-6203
000032195 8564_ $$s219804$$uhttps://zaguan.unizar.es/record/32195/files/texto_completo.pdf$$yVersión publicada
000032195 8564_ $$s93515$$uhttps://zaguan.unizar.es/record/32195/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000032195 909CO $$ooai:zaguan.unizar.es:32195$$particulos$$pdriver
000032195 951__ $$a2021-01-21-08:15:13
000032195 980__ $$aARTICLE