doi:10.1186/s13075-015-0789-9engSanada, K.Alda Díez, M.Salas Valero, M.Pérez-Yus, M.C.Demarzo, M.M.P.García-Toro, M.García-Campayo, J.Effects of non-pharmacological interventions on inflammatory biomarker expression in patients with fibromyalgia: A systematic reviewART-2015-92328Introduction: Fibromyalgia (FM) is a prevalent disorder. However, few studies have evaluated the effect of treatment interventions on biomarker expression. The aim of this review was to explore the efficacy of non-pharmacological interventions on inflammatory biomarker expression, specifically cytokines, neuropeptides and C-reactive protein (CRP), in FM patients. Method: A literature search using PubMed, EMBASE, PsycINFO and the Cochrane library was performed from January 1990 to March 2015. Randomized controlled trials (RCTs) and non-RCTs published in English, French or Spanish were eligible. Results: Twelve articles with a total of 536 participants were included. After exercise, multidisciplinary, or dietary interventions in FM patients, interleukin (IL) expression appeared reduced, specifically serum IL-8 and IL-6 (spontaneous, lipopolysaccharide (LPS)-induced, or serum). Furthermore, the changes to insulin-like growth factor 1 (IGF-1) levels might indicate a beneficial role for fatigue in obese FM patients. In contrast, evidence of changes in neuropeptide and CRP levels seemed inconsistent. Conclusion: Despite minimal evidence, our findings indicate that exercise interventions might act as an anti-inflammatory treatment in FM patients and ameliorate inflammatory status, especially for pro-inflammatory cytokines. Additional RCTs focused on the changes to inflammatory biomarker expression after non-pharmacological interventions in FM patients are needed.2015http://zaguan.unizar.es/record/3219610.1186/s13075-015-0789-9http://zaguan.unizar.es/record/32196oai:zaguan.unizar.es:32196info:eu-repo/grantAgreement/ES/MINECO/PSI2014-56303-REDTinfo:eu-repo/grantAgreement/ES/MICINN/ISCIII-RD06-0018-0017ARTHRITIS RESEARCH & THERAPY 17, 272 (2015), [16 pp.]by-nc-ndhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccess