32196 20210121082900.0 doi 10.1186/s13075-015-0789-9 sideral 92328 ART-2015-92328 eng Sanada, K. Effects of non-pharmacological interventions on inflammatory biomarker expression in patients with fibromyalgia: A systematic review 2015 Access copy available to the general public Unrestricted Introduction: Fibromyalgia (FM) is a prevalent disorder. However, few studies have evaluated the effect of treatment interventions on biomarker expression. The aim of this review was to explore the efficacy of non-pharmacological interventions on inflammatory biomarker expression, specifically cytokines, neuropeptides and C-reactive protein (CRP), in FM patients. Method: A literature search using PubMed, EMBASE, PsycINFO and the Cochrane library was performed from January 1990 to March 2015. Randomized controlled trials (RCTs) and non-RCTs published in English, French or Spanish were eligible. Results: Twelve articles with a total of 536 participants were included. After exercise, multidisciplinary, or dietary interventions in FM patients, interleukin (IL) expression appeared reduced, specifically serum IL-8 and IL-6 (spontaneous, lipopolysaccharide (LPS)-induced, or serum). Furthermore, the changes to insulin-like growth factor 1 (IGF-1) levels might indicate a beneficial role for fatigue in obese FM patients. In contrast, evidence of changes in neuropeptide and CRP levels seemed inconsistent. Conclusion: Despite minimal evidence, our findings indicate that exercise interventions might act as an anti-inflammatory treatment in FM patients and ameliorate inflammatory status, especially for pro-inflammatory cytokines. Additional RCTs focused on the changes to inflammatory biomarker expression after non-pharmacological interventions in FM patients are needed. info:eu-repo/grantAgreement/ES/MINECO/PSI2014-56303-REDT info:eu-repo/grantAgreement/ES/MICINN/ISCIII-RD06-0018-0017 info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 3.979 2015 RHEUMATOLOGY 8 / 31 = 0.258 2015 Q2 T1 1.955 2015 Immunology 2015 Q1 Rheumatology 2015 Q1 Immunology and Allergy 2015 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Alda Díez, M. (orcid)0000-0001-6261-3724 Salas Valero, M. (orcid)0000-0001-5566-9746 Pérez-Yus, M.C. Universidad de Zaragoza Demarzo, M.M.P. García-Toro, M. (orcid)0000-0002-3797-4218 García-Campayo, J. Universidad de Zaragoza 1007 745 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Psiquiatría 4009 680 Universidad de Zaragoza Dpto. Psicología y Sociología Área Person.Eval.Trat.Psicoló. 17, 272 (2015), [16 pp.] Arthritis res. ther. ARTHRITIS RESEARCH & THERAPY 1478-6354 1044190 http://zaguan.unizar.es/record/32196/files/texto_completo.pdf Versión publicada 105017 http://zaguan.unizar.es/record/32196/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:32196 articulos driver 2021-01-21-08:15:16 ARTICLE