000032197 001__ 32197
000032197 005__ 20210223082304.0
000032197 0247_ $$2doi$$a10.1371/journal.pone.0132244
000032197 0248_ $$2sideral$$a92331
000032197 037__ $$aART-2015-92331
000032197 041__ $$aeng
000032197 100__ $$aSaravia, G.
000032197 245__ $$aGlycated hemoglobin, fasting insulin and the metabolic syndrome in males. Cross-sectional analyses of the aragon workers health study baseline
000032197 260__ $$c2015
000032197 5060_ $$aAccess copy available to the general public$$fUnrestricted
000032197 5203_ $$aBackground and aims: Glycated hemoglobin (HbA1c) is currently used to diagnose diabetes mellitus, while insulin has been relegated to research. Both, however, may help understanding the metabolic syndrome and profiling patients. We examined the association of HbA1c and fasting insulin with clustering of metabolic syndrome criteria and insulin resistance as two essential characteristics of the metabolic syndrome. Methods: We used baseline data from 3200 non-diabetic male participants in the Aragon Workers' Health Study. We conducted analysis to estimate age-adjusted odds ratios (ORs) across tertiles of HbA1c and insulin. Fasting glucose and Homeostatic model assessment - Insulin Resistance were used as reference. Here we report the uppermost-to-lowest tertile ORs (95%CI). Results: Mean age (SD) was 48.5 (8.8) years and 23% of participants had metabolic syndrome. The ORs for metabolic syndrome criteria tended to be higher across HbA1c than across glucose, except for high blood pressure. Insulin was associated with the criteria more strongly than HbA1c and similarly to Homeostatic model assessment - Insulin Resistance (HOMA-IR). For metabolic syndrome, the OR of HbA1c was 2.68, of insulin, 11.36, of glucose, 7.03, and of HOMA-IR, 14.40. For the clustering of 2 or more non-glycemic criteria, the OR of HbA1c was 2.10, of insulin, 8.94, of glucose, 1.73, and of HOMA-IR, 7.83. All ORs were statistically significant. The areas under the receiver operating characteristics curves for metabolic syndrome were 0.670 (across HbA1c values) and 0.770 (across insulin values), and, for insulin resistance, 0.647 (HbA1c) and 0.995 (insulin). Among non-metabolic syndrome patients, a small insulin elevation identified risk factor clustering. Conclusions: HbA1c and specially insulin levels were associated with metabolic syndrome criteria, their clustering, and insulin resistance. Insulin could provide early information in subjects prone to develop metabolic syndrome.
000032197 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/RD12-0042-0055$$9info:eu-repo/grantAgreement/ES/ISCIII/PI12-01703$$9info:eu-repo/grantAgreement/ES/ISCIII/PI12-01087$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI14-00009$$9info:eu-repo/grantAgreement/ES/ISCIII-FIS/CP08-00112
000032197 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000032197 590__ $$a3.057$$b2015
000032197 591__ $$aMULTIDISCIPLINARY SCIENCES$$b11 / 62 = 0.177$$c2015$$dQ1$$eT1
000032197 592__ $$a1.427$$b2015
000032197 593__ $$aAgricultural and Biological Sciences (miscellaneous)$$c2015$$dQ1
000032197 593__ $$aMedicine (miscellaneous)$$c2015$$dQ1
000032197 593__ $$aBiochemistry, Genetics and Molecular Biology (miscellaneous)$$c2015$$dQ1
000032197 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000032197 700__ $$0(orcid)0000-0001-7043-0952$$aCiveira, F.$$uUniversidad de Zaragoza
000032197 700__ $$aHurtado-Roca, Y.
000032197 700__ $$aAndres, E.
000032197 700__ $$aLeon, M.
000032197 700__ $$0(orcid)0000-0001-8807-9187$$aPocovi, M.$$uUniversidad de Zaragoza
000032197 700__ $$aOrdovas, J.
000032197 700__ $$aGuallar, E.
000032197 700__ $$aFernandez-Ortiz, A.
000032197 700__ $$0(orcid)0000-0002-9887-2629$$aCasasnovas, J.A.$$uUniversidad de Zaragoza
000032197 700__ $$aLaclaustra, M.
000032197 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000032197 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole.
000032197 773__ $$g10, 8 (2015), 0132244 [14 p.]$$pPLoS One$$tPloS one$$x1932-6203
000032197 8564_ $$s1060320$$uhttps://zaguan.unizar.es/record/32197/files/texto_completo.pdf$$yVersión publicada
000032197 8564_ $$s99560$$uhttps://zaguan.unizar.es/record/32197/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000032197 909CO $$ooai:zaguan.unizar.es:32197$$particulos$$pdriver
000032197 951__ $$a2021-02-23-08:20:31
000032197 980__ $$aARTICLE