32208 20210121082905.0 doi 10.1007/s10439-015-1343-2 sideral 91011 ART-2015-91011 eng (orcid)0000-0001-7808-381X Moreno-Arotzena, O. Fibroblast migration in 3D is controlled by haptotaxis in a non-muscle myosin II-dependent manner 2015 Access copy available to the general public Unrestricted Cell migration in 3D is a key process in many physiological and pathological processes. Although valuable knowledge has been accumulated through analysis of various 2D models, some of these insights are not directly applicable to migration in 3D. In this study, we have confined biomimetic hydrogels within microfluidic platforms in the presence of a chemoattractant (platelet-derived growth fac- tor-BB). We have characterized the migratory responses of human fibroblasts within them, particularly focusing on the role of non-muscle myosin II. Our results indicate a prominent role for myosin II in the integration of chemo- tactic and haptotactic migratory responses of fibroblasts in 3D confined environments. info:eu-repo/grantAgreement/EUR/FP7/ERC2012-StG-306751 info:eu-repo/grantAgreement/ES/MINECO/DPI2012-38090-C03-01 info:eu-repo/grantAgreement/ES/MINECO/SAF2011-24953 info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 2.887 2015 ENGINEERING, BIOMEDICAL 16 / 76 = 0.211 2015 Q1 T1 1.2 2015 Biomedical Engineering 2015 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion (orcid)0000-0002-3784-1140 Borau, C. Universidad de Zaragoza (orcid)0000-0002-0163-8378 Movilla, N. Vicente-Manzanares, M. (orcid)0000-0002-9864-7683 García-Aznar, J.M. Universidad de Zaragoza 5004 605 Universidad de Zaragoza Dpto. Ingeniería Mecánica Área Mec.Med.Cont. y Teor.Est. 43, 12 (2015), 3025-3039 Ann. biomed. eng. Annals of Biomedical Engineering 0090-6964 2958724 http://zaguan.unizar.es/record/32208/files/texto_completo.pdf Versión publicada 95012 http://zaguan.unizar.es/record/32208/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:32208 articulos driver 2021-01-21-08:17:39 ARTICLE