000032217 001__ 32217
000032217 005__ 20210121082901.0
000032217 0247_ $$2doi$$a10.3390/md13095666
000032217 0248_ $$2sideral$$a92243
000032217 037__ $$aART-2015-92243
000032217 041__ $$aeng
000032217 100__ $$0(orcid)0000-0003-1892-5063$$aCeballos-Laita, L.
000032217 245__ $$agamma-Lindane increases microcystin synthesis in microcystis aeruginosa PCC7806
000032217 260__ $$c2015
000032217 5060_ $$aAccess copy available to the general public$$fUnrestricted
000032217 5203_ $$aHCH factories, and the waste dumpsites associated to its production, have become a global environmental concern, and their runoff could pollute ground and surface waters with high levels of the pollutant. In this study, the influence of lindane (¿-HCH) on microcystin production has been investigated in Microcystis aeruginosa PCC7806. This toxic cyanobacterium is highly tolerant to ¿-lindane (20 mg/L), and produces more toxin (microcystin) in the presence of the pollutant. Microcystis degrades ¿-lindane and presence of ¿-lindane induces genes involved in its own degradation (nirA). RT-PCRsq has been used to monitor changes in levels of transcripts encoded by the mcy operon (mcyD, mcyH and mcyJ), responsible for the microcystin synthesis machinery, as well as other genes involved in its transcriptional regulation, such as ntcA and fur family members. The presence of lindane in the culture media induces mcyD expression, as well as ntcA gene transcription, while other genes, such as mcyH, (putative ABC transporter), are downregulated. The amount of microcystin found in the cells and the culture media is higher when M. aeruginosa is treated with ¿-lindane than in control cells. The results\ suggest that in a lindane polluted environment, Microcystis toxic strains may enhance their microcystin synthesis.
000032217 536__ $$9info:eu-repo/grantAgreement/ES/MINECO/BFU2012-31458
000032217 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000032217 590__ $$a3.345$$b2015
000032217 591__ $$aCHEMISTRY, MEDICINAL$$b13 / 59 = 0.22$$c2015$$dQ1$$eT1
000032217 592__ $$a0.775$$b2015
000032217 593__ $$aDrug Discovery$$c2015$$dQ2
000032217 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000032217 700__ $$0(orcid)0000-0001-5327-4046$$aCalvo-Begueria, L.
000032217 700__ $$aLahoz, J.
000032217 700__ $$0(orcid)0000-0002-8181-2689$$aBes, M.T$$uUniversidad de Zaragoza
000032217 700__ $$0(orcid)0000-0001-8644-4574$$aFillat, M.F.$$uUniversidad de Zaragoza
000032217 700__ $$0(orcid)0000-0002-2742-3711$$aPeleato, M.L$$uUniversidad de Zaragoza
000032217 7102_ $$11002$$2412$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Fisiología Vegetal
000032217 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole.
000032217 773__ $$g13, 9 (2015), 5666-5680$$pMarine Drugs$$tMarine Drugs$$x1660-3397
000032217 8564_ $$s610932$$uhttps://zaguan.unizar.es/record/32217/files/texto_completo.pdf$$yVersión publicada
000032217 8564_ $$s93928$$uhttps://zaguan.unizar.es/record/32217/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000032217 909CO $$ooai:zaguan.unizar.es:32217$$particulos$$pdriver
000032217 951__ $$a2021-01-21-08:16:09
000032217 980__ $$aARTICLE