000032459 001__ 32459 000032459 005__ 20190329083156.0 000032459 0247_ $$2doi$$a10.1016/j.crohns.2013.08.010 000032459 0248_ $$2sideral$$a85180 000032459 037__ $$aART-2014-85180 000032459 041__ $$aeng 000032459 100__ $$aAndreu, M. 000032459 245__ $$aDisease severity in familial cases of IBD 000032459 260__ $$c2014 000032459 5060_ $$aAccess copy available to the general public$$fUnrestricted 000032459 5203_ $$aBackground: Phenotypic traits of familial IBD relative to sporadic cases are controversial, probably related to limited statistical power of published evidence. Aim: To know if there are phenotype differences between familial and sporadic IBD, evaluating the prospective Spanish registry (ENEIDA) with 11,983 cases. Methods: 5783 patients (48.3%) had ulcerative colitis (UC) and 6200 (51.7%) Crohn's disease (CD). Cases with one or more 1st, 2nd or 3rd degree relatives affected by UC/CD were defined as familial case. Results: In UC and CD, familial cases compared with sporadic cases had an earlier disease onset (UC: 33 years [IQR 25–44] vs 37 years [IQR 27–49]; p b 0.0001); (CD: 27 years [IQR 21–35] vs 29 years [IQR 22–40]; p b 0.0001), higher prevalence of extraintestinal immune-related manifestations (EIMs) (UC: 17.2% vs 14%; p = 0.04); (CD: 30.1% vs 23.6%; p b 0.0001). Familial CD had higher percentage of ileocolic location (42.7% vs 51.8%; p = 0.0001), penetrating behavior (21% vs 17.6%; p = 0.01) and perianal disease (32% vs 27.1%; p = 0.003). Differences are not influenced by degree of consanguinity. Conclusion: When a sufficiently powered cohort is evaluated, familial aggregation in IBD is associated to an earlier disease onset, more EIMs and more severe phenotype in CD. This feature should be taken into account at establishing predictors of disease course. 000032459 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/ 000032459 590__ $$a6.234$$b2014 000032459 591__ $$aGASTROENTEROLOGY & HEPATOLOGY$$b8 / 76 = 0.105$$c2014$$dQ1$$eT1 000032459 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000032459 700__ $$aMárquez, L. 000032459 700__ $$aDomènech, E. 000032459 700__ $$aGisbert, J.P. 000032459 700__ $$aGarcía, V. 000032459 700__ $$aMarín-Jiménez, I. 000032459 700__ $$aPeñalva, M. 000032459 700__ $$0(orcid)0000-0003-0076-3529$$aGomollón, F.$$uUniversidad de Zaragoza 000032459 700__ $$aCalvet, X. 000032459 700__ $$aMerino, O. 000032459 700__ $$aGarcia-Planella, E. 000032459 700__ $$aVázquez-Romero, N. 000032459 700__ $$aEsteve, M. 000032459 700__ $$aNos, P. 000032459 700__ $$aGutiérrez, A. 000032459 700__ $$aVera, I. 000032459 700__ $$aCabriada, J.L. 000032459 700__ $$aMartín, M.D. 000032459 700__ $$aCañas-Ventura, A. 000032459 700__ $$aPanés, J. 000032459 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina 000032459 773__ $$g8, 3 (2014), 234-239$$pJournal of Crohns & Colitis$$tJournal of Crohns & Colitis$$x1873-9946 000032459 8564_ $$s247391$$uhttps://zaguan.unizar.es/record/32459/files/texto_completo.pdf$$yVersión publicada 000032459 8564_ $$s102191$$uhttps://zaguan.unizar.es/record/32459/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000032459 909CO $$ooai:zaguan.unizar.es:32459$$particulos$$pdriver 000032459 951__ $$a2019-03-29-08:29:52 000032459 980__ $$aARTICLE