000032465 001__ 32465
000032465 005__ 20170504094306.0
000032465 0247_ $$2doi$$a10.1186/1471-2466-14-123
000032465 0248_ $$2sideral$$a87635
000032465 037__ $$aART-2014-87635
000032465 041__ $$aeng
000032465 100__ $$0(orcid)0000-0003-3670-2664$$aBello, S.$$uUniversidad de Zaragoza
000032465 245__ $$aInflammatory response in mixed viral-bacterial community-acquired pneumonia
000032465 260__ $$c2014
000032465 5060_ $$aAccess copy available to the general public$$fUnrestricted
000032465 5203_ $$aBackground
The role of mixed pneumonia (virus¿+¿bacteria) in community-acquired pneumonia (CAP) has been described in recent years. However, it is not known whether the systemic inflammatory profile is different compared to monomicrobial CAP. We wanted to investigate this profile of mixed viral-bacterial infection and to compare it to monomicrobial bacterial or viral CAP.
Methods
We measured baseline serum procalcitonin (PCT), C reactive protein (CRP), and white blood cell (WBC) count in 171 patients with CAP with definite etiology admitted to a tertiary hospital: 59 (34.5%) bacterial, 66 (39.%) viral and 46 (27%) mixed (viral-bacterial).
Results
Serum PCT levels were higher in mixed and bacterial CAP compared to viral CAP. CRP levels were higher in mixed CAP compared to the other groups. CRP was independently associated with mixed CAP. CRP levels below 26 mg/dL were indicative of an etiology other than mixed in 83% of cases, but the positive predictive value was 45%. PCT levels over 2.10 ng/mL had a positive predictive value for bacterial-involved CAP versus viral CAP of 78%, but the negative predictive value was 48%.
Conclusions
Mixed CAP has a different inflammatory pattern compared to bacterial or viral CAP. High CRP levels may be useful for clinicians to suspect mixed CAP.
000032465 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000032465 590__ $$a2.404$$b2014
000032465 591__ $$aRESPIRATORY SYSTEM$$b31 / 57 = 0.544$$c2014$$dQ3$$eT2
000032465 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000032465 700__ $$aMincholé, E.
000032465 700__ $$aFandos, S.
000032465 700__ $$aLasierra, A.B.
000032465 700__ $$aRuiz, M.A.
000032465 700__ $$aSimon, A.L.
000032465 700__ $$aPanadero, C.
000032465 700__ $$aLapresta, C.
000032465 700__ $$aMenendez, R.
000032465 700__ $$aTorres, A.
000032465 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDepartamento de Medicina, Psiquiatría y Dermatología$$cMedicina
000032465 773__ $$g14, 123 (2014), [13 pp.]$$pBMC polm. med.$$tBMC pulmonary medicine$$x1471-2466
000032465 8564_ $$s786632$$uhttps://zaguan.unizar.es/record/32465/files/texto_completo.pdf$$yVersión publicada
000032465 8564_ $$s107621$$uhttps://zaguan.unizar.es/record/32465/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000032465 909CO $$ooai:zaguan.unizar.es:32465$$particulos$$pdriver
000032465 951__ $$a2017-05-04-09:41:34
000032465 980__ $$aARTICLE