000032479 001__ 32479
000032479 005__ 20180626080119.0
000032479 0247_ $$2doi$$a10.1371/journal.pone.0089828
000032479 0248_ $$2sideral$$a92369
000032479 037__ $$aART-2014-92369
000032479 041__ $$aeng
000032479 100__ $$aGarcía-Calzón, S.
000032479 245__ $$aTelomere length as a biomarker for adiposity changes after a multidisciplinary intervention in overweight/obese adolescents: The EVASYON study
000032479 260__ $$c2014
000032479 5060_ $$aAccess copy available to the general public$$fUnrestricted
000032479 5203_ $$aContext: Telomeres are biomarkers of biological aging. Shorter telomeres have been associated with increased adiposity in adults. However, this relationship remains unclear in children and adolescents. Objective: To evaluate the association between telomere length (TL) and adiposity markers in overweight/obese adolescents after an intensive program. We hypothesize that greater TL at baseline would predict a better response to a weight loss treatment. Design, Setting, Patients and Intervention: The EVASYON is a multidisciplinary treatment program for adolescents with overweight and obesity that is aimed at applying the intervention to all possibly involved areas of the individual, such as dietary habits, physical activity and cognitive and psychological profiles. Seventy-four participants (36 males, 38 females, 12-16 yr) were enrolled in the intervention program: 2 months of an energy-restricted diet and a follow-up period (6 months). Main Outcome: TL was measured by quantitative real-time polymerase chain reaction at baseline and after 2 months; meanwhile, anthropometric variables were also assessed after 6 months of follow-up. Results: TL lengthened in participants during the intensive period (+1.9±1.0, p<0.001) being greater in overweight/obese adolescents with the shortest telomeres at baseline (r = -0.962, p<0.001). Multivariable linear regression analysis showed that higher baseline TL significantly predicted a higher decrease in body weight (B = -1.53, p = 0.005; B = -2.25, p = 0.047) and in standard deviation score for body mass index (BMI-SDS) (B = -0.22, p = 0.010; B = -0.47, p = 0.005) after the intensive and extensive period treatment respectively, in boys. Conclusion: Our study shows that a weight loss intervention is accompanied by a significant increase in TL in overweight/obese adolescents. Moreover, we suggest that initial longer TL could be a potential predictor for a better weight loss response.
000032479 536__ $$9info:eu-repo/grantAgreement/ES/MINECO/FIS/PI051579$$9info:eu-repo/grantAgreement/ES/MINECO/FIS/PI051080$$9info:eu-repo/grantAgreement/ES/MICINN/SAF2010-20367$$9info:eu-repo/grantAgreement/ES/ISCIII/CB06-03-1017
000032479 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000032479 590__ $$a3.234$$b2014
000032479 591__ $$aMULTIDISCIPLINARY SCIENCES$$b9 / 57 = 0.158$$c2014$$dQ1$$eT1
000032479 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000032479 700__ $$aMoleres, A.
000032479 700__ $$aMarcos, A.
000032479 700__ $$aCampoy, C.
000032479 700__ $$0(orcid)0000-0003-0454-653X$$aMoreno, L.A.$$uUniversidad de Zaragoza
000032479 700__ $$aAzcona-Sanjulián, M.C.
000032479 700__ $$aMartínez-González, M.A.
000032479 700__ $$aMartínez, A.
000032479 700__ $$aZalba, G.
000032479 700__ $$aMarti, A.
000032479 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDepartamento de Fisiatría y Enfermería$$cEnfermería
000032479 773__ $$g9, 2 (2014), e89828 [8 pp.]$$pPLoS One$$tPLoS ONE$$x1932-6203
000032479 8564_ $$s322677$$uhttps://zaguan.unizar.es/record/32479/files/texto_completo.pdf$$yVersión publicada
000032479 8564_ $$s109119$$uhttps://zaguan.unizar.es/record/32479/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000032479 909CO $$ooai:zaguan.unizar.es:32479$$particulos$$pdriver
000032479 951__ $$a2018-06-26-07:57:16
000032479 980__ $$aARTICLE