doi:10.3390/sym7031519engSonsona, I.G.Marqués-López, E.Herrera, R.P.Enantioselective organocatalyzed synthesis of 2-amino-3-cyano-4H-chromene derivativesART-2015-92969The structural motif that results from the fusion of a benzene ring to a heterocyclic pyran ring, known as chromene, is broadly found in nature and it has been reported to be associated with a wide range of biological activity. Moreover, asymmetric organocatalysis is a discipline in expansion that is already recognized as a well-established tool for obtaining enantiomerically enriched compounds. This review covers the particular case of the asymmetric synthesis of 2-amino-3-cyano-4H-chromenes using organocatalysis. Herein, we show the most illustrative examples of the methods developed by diverse research groups, following a classification based on these five different approaches: (1) addition of naphthol compounds to substituted a, a-dicyanoolefins; (2) addition of malononitrile to substituted o-vinylphenols; (3) addition of malononitrile to N-protected o-iminophenols; (4) Michael addition of nucleophiles to 2-iminochromene derivatives; and (5) organocatalyzed formal 4+2] cycloaddition reaction. In most cases, chiral thioureas have been found to be effective catalysts to promote the synthetic processes, and generally a bifunctional mode of action has been envisioned for them. In addition, squaramides and cinchona derivatives have been occasionally used as suitable catalysts for the substrates activation.2015http://zaguan.unizar.es/record/3276810.3390/sym7031519http://zaguan.unizar.es/record/32768oai:zaguan.unizar.es:32768info:eu-repo/grantAgreement/ES/DGA/E104info:eu-repo/grantAgreement/ES/MICINN/CTQ2013-44367-C2-1-Pinfo:eu-repo/grantAgreement/ES/UZ/JIUZ-2014-CIE-07SYMMETRY-BASEL 7, 3 (2015), 1519-1535byhttp://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccess