32800 20210121082902.0 doi 10.1016/j.cmpb.2015.09.018 sideral 92355 ART-2015-92355 eng (orcid)0000-0002-6305-9283 Manzano Martínez, Sara Universidad de Zaragoza Parameter-dependent behavior of articular cartilage: 3D mechano-electrochemical computational model 2015 Access copy available to the general public Unrestricted Background and objective Changes in mechano-electrochemical properties of articular cartilage play an essential role in the majority of cartilage diseases. Despite of this importance, the specific effect of each parameter into tissue behavior remains still obscure. Parametric computational modeling of cartilage can provide some insights into this matter, specifically the study of mechano-electrochemical properties variation and their correlation with tissue swelling, water and ion fluxes. Thus, the aim of this study is to evaluate the influence of the main mechanical and electrochemical parameters on the determination of articular cartilage behavior by a parametric analysis through a 3D finite element model. Methods For this purpose, a previous 3D mechano-electrochemical model, developed by the same authors, of articular cartilage behavior has been used. Young's modulus, Poisson coefficient, ion diffusivities and ion activity coefficients variations have been analyzed and quantified through monitoring tissue simulated response. Results Simulation results show how Young's modulus and Poisson coefficient control tissue behavior rather than electrochemical properties. Meanwhile, ion diffusivity and ion activity coefficients appear to be vital in controlling velocity of incoming and outgoing fluxes. Conclusions This parametric study establishes a basic guide when defining the main properties that are essential to be included into computational modeling of articular cartilage providing a helpful tool in tissue simulations. info:eu-repo/grantAgreement/ES/MEC/FPU-AP2010-2557 info:eu-repo/grantAgreement/ES/MINECO/MAT2013-46467-C4-3-R info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 1.862 2015 COMPUTER SCIENCE, THEORY & METHODS 16 / 105 = 0.152 2015 Q1 T1 ENGINEERING, BIOMEDICAL 35 / 76 = 0.461 2015 Q2 T2 COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS 37 / 104 = 0.356 2015 Q2 T2 MEDICAL INFORMATICS 10 / 20 = 0.5 2015 Q2 T2 0.849 2015 Computer Science Applications 2015 Q1 Software 2015 Q1 Health Informatics 2015 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/submittedVersion (orcid)0000-0001-8741-6452 Doblaré Castellano, Manuel Universidad de Zaragoza (orcid)0000-0003-0088-7222 Hamdy Doweidar, Mohamed Universidad de Zaragoza 5004 605 Universidad de Zaragoza Dpto. Ingeniería Mecánica Área Mec.Med.Cont. y Teor.Est. 122, 3 (2015), 491–502 Comput. methods programs biomed. Computer Methods and Programs in Biomedicine 0169-2607 1064954 http://zaguan.unizar.es/record/32800/files/texto_completo.pdf Preprint 38260 http://zaguan.unizar.es/record/32800/files/texto_completo.jpg?subformat=icon icon Preprint oai:zaguan.unizar.es:32800 articulos driver 2021-01-21-08:16:31 ARTICLE