000046545 001__ 46545 000046545 005__ 20210121114538.0 000046545 0247_ $$2doi$$a10.1371/journal.pone.0126096 000046545 0248_ $$2sideral$$a93303 000046545 037__ $$aART-2015-93303 000046545 041__ $$aeng 000046545 100__ $$aCastelló, A. 000046545 245__ $$aLower breast cancer risk among women following the World Cancer Research Fund and American Institute for Cancer Research lifestyle recommendations: Epigeicam case-control study 000046545 260__ $$c2015 000046545 5060_ $$aAccess copy available to the general public$$fUnrestricted 000046545 5203_ $$aBackground: According to the "World Cancer Research Fund" and the "American Institute of Cancer Research" (WCRF/AICR) one in four cancer cases could be prevented through a healthy diet, weight control and physical activity. Objective: To explore the association between the WCRF/AICR recommendations and risk of breast cancer. Methods: During the period 2006 to 2011 we recruited 973 incident cases of breast cancer and 973 controls from 17 Spanish Regions. We constructed a score based on 9 of the WCRF/AICR recommendations for cancer prevention:: 1)Maintain adequate body weight; 2)Be physically active; 3)Limit the intake of high density foods; 4)Eat mostly plant foods; 5)Limit the intake of animal foods; 6)Limit alcohol intake; 7)Limit salt and salt preserved food intake; 8)Meet nutritional needs through diet; S1)Breastfeed infants exclusively up to 6 months. We explored its association with BC by menopausal status and by intrinsic tumor subtypes (ER +/PR+ & HER2-; HER2+; ER&PR-&HER2-) using conditional and multinomial logistic models respectively. Results: Our results point to a linear association between the degree of noncompliance and breast cancer risk. Taking women who met 6 or more recommendations as reference, those meeting less than 3 showed a three-fold excess risk (OR=2.98(CI95%:1.59-5.59)), especially for postmenopausal women (OR=3.60(CI95%:1.24;10.47)) and ER+/PR+&HER2-(OR=3.60 (CI95%:1.84;7.05)) and HER2+ (OR=4.23(CI95%:1.66;10.78)) tumors. Noncompliance of recommendations regarding the consumption of foods and drinks that promote weight gain in premenopausal women (OR=2.24(CI95%:1.18;4.28); p for interaction=0.014) and triple negative tumors (OR=2.93(CI95%:1.12-7.63)); the intake of plant foods in postmenopausal women (OR=2.35(CI95%:1.24;4.44)) and triple negative tumors (OR=3.48(CI95%:1.46-8.31)); and the alcohol consumption in ER+/PR+&HER2-tumors (OR=1.52 (CI95%:1.06-2.19)) showed the strongest associations. Conclusion: Breast cancer prevention might be possible by following the "World Cancer Research Fund" and the "American Institute of Cancer Research" recommendations, even in settings like Spain, where a high percentage of women already comply with many of them. 000046545 536__ $$9info:eu-repo/grantAgreement/ES/MINECO/FIS/CD110-00018 000046545 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000046545 590__ $$a3.057$$b2015 000046545 591__ $$aMULTIDISCIPLINARY SCIENCES$$b11 / 62 = 0.177$$c2015$$dQ1$$eT1 000046545 592__ $$a1.427$$b2015 000046545 593__ $$aAgricultural and Biological Sciences (miscellaneous)$$c2015$$dQ1 000046545 593__ $$aMedicine (miscellaneous)$$c2015$$dQ1 000046545 593__ $$aBiochemistry, Genetics and Molecular Biology (miscellaneous)$$c2015$$dQ1 000046545 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000046545 700__ $$aMartín, M. 000046545 700__ $$aRuiz, A. 000046545 700__ $$aCasas, A.M. 000046545 700__ $$aBaena-Cañada, J.M. 000046545 700__ $$aLope, V. 000046545 700__ $$aAntolín, S. 000046545 700__ $$aSánchez, P. 000046545 700__ $$aRamos, M. 000046545 700__ $$0(orcid)0000-0002-9159-4988$$aAntón, A.$$uUniversidad de Zaragoza 000046545 700__ $$aMuñoz, M. 000046545 700__ $$aBermejo, B. 000046545 700__ $$aDe Juan-Ferré, A. 000046545 700__ $$aJara, C. 000046545 700__ $$aChacón, J.I. 000046545 700__ $$aJimeno, M.A. 000046545 700__ $$aRosado, P. 000046545 700__ $$aDíaz, E. 000046545 700__ $$aGuillem, V. 000046545 700__ $$aLluch, A. 000046545 700__ $$aCarrasco, E. 000046545 700__ $$aPérez-Gómez, B. 000046545 700__ $$aVioque, J. 000046545 700__ $$aPollán, M. 000046545 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina 000046545 773__ $$g10, 5 (2015), 0126096 [15 pp]$$pPLoS One$$tPloS one$$x1932-6203 000046545 8564_ $$s219002$$uhttps://zaguan.unizar.es/record/46545/files/texto_completo.pdf$$yVersión publicada 000046545 8564_ $$s99708$$uhttps://zaguan.unizar.es/record/46545/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000046545 909CO $$ooai:zaguan.unizar.es:46545$$particulos$$pdriver 000046545 951__ $$a2021-01-21-11:14:42 000046545 980__ $$aARTICLE