doi:10.1371/journal.pone.0126096engCastelló, A.Martín, M.Ruiz, A.Casas, A.M.Baena-Cañada, J.M.Lope, V.Antolín, S.Sánchez, P.Ramos, M.Antón, A.Muñoz, M.Bermejo, B.De Juan-Ferré, A.Jara, C.Chacón, J.I.Jimeno, M.A.Rosado, P.Díaz, E.Guillem, V.Lluch, A.Carrasco, E.Pérez-Gómez, B.Vioque, J.Pollán, M.Lower breast cancer risk among women following the World Cancer Research Fund and American Institute for Cancer Research lifestyle recommendations: Epigeicam case-control studyART-2015-93303Background: According to the "World Cancer Research Fund" and the "American Institute of Cancer Research" (WCRF/AICR) one in four cancer cases could be prevented through a healthy diet, weight control and physical activity. Objective: To explore the association between the WCRF/AICR recommendations and risk of breast cancer. Methods: During the period 2006 to 2011 we recruited 973 incident cases of breast cancer and 973 controls from 17 Spanish Regions. We constructed a score based on 9 of the WCRF/AICR recommendations for cancer prevention:: 1)Maintain adequate body weight; 2)Be physically active; 3)Limit the intake of high density foods; 4)Eat mostly plant foods; 5)Limit the intake of animal foods; 6)Limit alcohol intake; 7)Limit salt and salt preserved food intake; 8)Meet nutritional needs through diet; S1)Breastfeed infants exclusively up to 6 months. We explored its association with BC by menopausal status and by intrinsic tumor subtypes (ER +/PR+ & HER2-; HER2+; ER&PR-&HER2-) using conditional and multinomial logistic models respectively. Results: Our results point to a linear association between the degree of noncompliance and breast cancer risk. Taking women who met 6 or more recommendations as reference, those meeting less than 3 showed a three-fold excess risk (OR=2.98(CI95%:1.59-5.59)), especially for postmenopausal women (OR=3.60(CI95%:1.24;10.47)) and ER+/PR+&HER2-(OR=3.60 (CI95%:1.84;7.05)) and HER2+ (OR=4.23(CI95%:1.66;10.78)) tumors. Noncompliance of recommendations regarding the consumption of foods and drinks that promote weight gain in premenopausal women (OR=2.24(CI95%:1.18;4.28); p for interaction=0.014) and triple negative tumors (OR=2.93(CI95%:1.12-7.63)); the intake of plant foods in postmenopausal women (OR=2.35(CI95%:1.24;4.44)) and triple negative tumors (OR=3.48(CI95%:1.46-8.31)); and the alcohol consumption in ER+/PR+&HER2-tumors (OR=1.52 (CI95%:1.06-2.19)) showed the strongest associations. Conclusion: Breast cancer prevention might be possible by following the "World Cancer Research Fund" and the "American Institute of Cancer Research" recommendations, even in settings like Spain, where a high percentage of women already comply with many of them.2015http://zaguan.unizar.es/record/4654510.1371/journal.pone.0126096http://zaguan.unizar.es/record/46545oai:zaguan.unizar.es:46545info:eu-repo/grantAgreement/ES/MINECO/FIS/CD110-00018PloS one 10, 5 (2015), 0126096 [15 pp]byhttp://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccess