000046558 001__ 46558
000046558 005__ 20210121114548.0
000046558 0247_ $$2doi$$a10.1371/journal.pone.0122094
000046558 0248_ $$2sideral$$a89451
000046558 037__ $$aART-2015-89451
000046558 041__ $$aeng
000046558 100__ $$0(orcid)0000-0003-0509-1450$$aSeyed Jamaleddin, Mousavi$$uUniversidad de Zaragoza
000046558 245__ $$aThree-Dimensional Numerical Model of Cell Morphology during Migration in Multi-Signaling Substrates
000046558 260__ $$c2015
000046558 5060_ $$aAccess copy available to the general public$$fUnrestricted
000046558 5203_ $$aCell Migration associated with cell shape changes are of central importance in many biological processes ranging from morphogenesis to metastatic cancer cells. Cell movement is a result of cyclic changes of cell morphology due to effective forces on cell body, leading to periodic fluctuations of the cell length and cell membrane area. It is well-known that the cell can be guided by different effective stimuli such as mechanotaxis, thermotaxis, chemotaxis and/or electrotaxis. Regulation of intracellular mechanics and cell’s physical interaction with its substrate rely on control of cell shape during cell migration. In this notion, it is essential to understand how each natural or external stimulus may affect the cell behavior. Therefore, a three-dimensional (3D) computational model is here developed to analyze a free mode of cell shape changes during migration in a multi-signaling micro-environment. This model is based on previous models that are presented by the same authors to study cell migration with a constant spherical cell shape in a multi-signaling substrates and mechanotaxis effect on cell morphology. Using the finite element discrete methodology, the cell is represented by a group of finite elements. The cell motion is modeled by equilibrium of effective forces on cell body such as traction, protrusion, electrostatic and drag forces, where the cell traction force is a function of the cell internal deformations. To study cell behavior in the presence of different stimuli, the model has been employed in different numerical cases. Our findings, which are qualitatively consistent with well-known related experimental observations, indicate that adding a new stimulus to the cell substrate pushes the cell to migrate more directionally in more elongated form towards the more effective stimuli. For instance, the presence of thermotaxis, chemotaxis and electrotaxis can further move the cell centroid towards the corresponding stimulus, respectively, diminishing the mechanotaxis effect. Besides, the stronger stimulus imposes a greater cell elongation and more cell membrane area. The present model not only provides new insights into cell morphology in a multi-signaling micro-environment but also enables us to investigate in more precise way the cell migration in the presence of different stimuli.
000046558 536__ $$9info:eu-repo/grantAgreement/ES/MINECO/MAT2013-46467-C4-3-R
000046558 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000046558 590__ $$a3.057$$b2015
000046558 591__ $$aMULTIDISCIPLINARY SCIENCES$$b11 / 62 = 0.177$$c2015$$dQ1$$eT1
000046558 592__ $$a1.427$$b2015
000046558 593__ $$aAgricultural and Biological Sciences (miscellaneous)$$c2015$$dQ1
000046558 593__ $$aMedicine (miscellaneous)$$c2015$$dQ1
000046558 593__ $$aBiochemistry, Genetics and Molecular Biology (miscellaneous)$$c2015$$dQ1
000046558 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000046558 700__ $$0(orcid)0000-0003-0088-7222$$aHamdy Doweidar, Mohamed$$uUniversidad de Zaragoza
000046558 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est.
000046558 773__ $$g10, 3 (2015), e012209[33 pp.]$$pPLoS One$$tPloS one$$x1932-6203
000046558 8564_ $$s3294893$$uhttps://zaguan.unizar.es/record/46558/files/texto_completo.pdf$$yVersión publicada
000046558 8564_ $$s109883$$uhttps://zaguan.unizar.es/record/46558/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000046558 909CO $$ooai:zaguan.unizar.es:46558$$particulos$$pdriver
000046558 951__ $$a2021-01-21-11:20:23
000046558 980__ $$aARTICLE