000046911 001__ 46911
000046911 005__ 20210121114549.0
000046911 0247_ $$2doi$$a10.3390/ma8085154
000046911 0248_ $$2sideral$$a91958
000046911 037__ $$aART-2015-91958
000046911 041__ $$aeng
000046911 100__ $$aAndreu, V.
000046911 245__ $$aSmart dressings based on nanostructured fibers containing natural origin antimicrobial, anti-inflammatory, and regenerative compounds
000046911 260__ $$c2015
000046911 5060_ $$aAccess copy available to the general public$$fUnrestricted
000046911 5203_ $$aA fast and effective wound healing process would substantially decrease medical costs, wound care supplies, and hospitalization significantly improving the patients’ quality of life. The search for effective therapeutic approaches seems to be imperative in order to avoid the aggravation of chronic wounds. In spite of all the efforts that have been made during the recent years towards the development of artificial wound dressings, none of the currently available options combine all the requirements necessary for quick and optimal cutaneous regeneration. Therefore, technological advances in the area of temporary and permanent smart dressings for wound care are required. The development of nanoscience and nanotechnology can improve the materials and designs used in topical wound care in order to efficiently release antimicrobial, anti-inflammatory and regenerative compounds speeding up the endogenous healing process. Nanostructured dressings can overcome the limitations of the current coverings and, separately, natural origin components can also overcome the drawbacks of current antibiotics and antiseptics (mainly cytotoxicity, antibiotic resistance, and allergies). The combination of natural origin components with demonstrated antibiotic, regenerative, or anti-inflammatory nanostructured materials is a promising approach to fulfil all the requirements needed for the next generation of bioactive wound dressings. Microbially compromised wounds have been treated with different essential oils, honey, cationic peptides, aloe vera, plant extracts, and other natural origin occurring antimicrobial, anti-inflammatory, and regenerative components but the available evidence is limited and insufficient to be able to draw reliable conclusions and to extrapolate those findings to the clinical practice. The evidence and some promising preliminary results indicate that future comparative studies are justified but instead of talking about the beneficial or inert effects of those natural origin occurring materials, the scientific community leads towards the identification of the main active components involved and their mechanism of action during the corresponding healing, antimicrobial, or regenerative processes and in carrying out systematic and comparative controlled tests. Once those natural origin components have been identified and their efficacy validated through solid clinical trials, their combination within nanostructured dressings can open up new avenues in the fabrication of bioactive dressings with outstanding characteristics for wound care. The motivation of this work is to analyze the state of the art in the use of different essential oils, honey, cationic peptides, aloe vera, plant extracts, and other natural origin occurring materials as antimicrobial, anti-inflammatory and regenerative components with the aim of clarifying their potential clinical use in bioactive dressings. We conclude that, for those natural occurring materials, more clinical trials are needed to reach a sufficient level of evidence as therapeutic agents for wound healing management.properties together with
000046911 536__ $$9info:eu-repo/grantAgreement/EC/FP7/614715/EU/A Photo-triggered On-demand Drug Delivery System for Chronic Pain/NANOHEDONISM
000046911 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000046911 590__ $$a2.728$$b2015
000046911 591__ $$aMATERIALS SCIENCE, MULTIDISCIPLINARY$$b63 / 271 = 0.232$$c2015$$dQ1$$eT1
000046911 592__ $$a0.83$$b2015
000046911 593__ $$aMaterials Science (miscellaneous)$$c2015$$dQ1
000046911 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000046911 700__ $$aMendoza, G.
000046911 700__ $$0(orcid)0000-0003-3165-0156$$aArruebo, M.$$uUniversidad de Zaragoza
000046911 700__ $$0(orcid)0000-0002-2966-9088$$aIrusta, S.$$uUniversidad de Zaragoza
000046911 7102_ $$15005$$2555$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Ingeniería Química
000046911 773__ $$g8, 8 (2015), 5154-5193$$pMATERIALS$$tMATERIALS$$x1996-1944
000046911 8564_ $$s2415163$$uhttps://zaguan.unizar.es/record/46911/files/texto_completo.pdf$$yVersión publicada
000046911 8564_ $$s92026$$uhttps://zaguan.unizar.es/record/46911/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000046911 909CO $$ooai:zaguan.unizar.es:46911$$particulos$$pdriver
000046911 951__ $$a2021-01-21-11:20:35
000046911 980__ $$aARTICLE