000046913 001__ 46913 000046913 005__ 20190930125518.0 000046913 0247_ $$2doi$$a10.1186/2196-050X-1-2 000046913 0248_ $$2sideral$$a91009 000046913 037__ $$aART-2014-91009 000046913 041__ $$aeng 000046913 100__ $$0(orcid)0000-0002-3784-1140$$aBorau, Carlos$$uUniversidad de Zaragoza 000046913 245__ $$aProbabilistic Voxel-Fe model for single cell motility in 3D 000046913 260__ $$c2014 000046913 5060_ $$aAccess copy available to the general public$$fUnrestricted 000046913 5203_ $$aBackground: Cells respond to a variety of external stimuli regulated by the environment conditions. Mechanical, chemical and biological factors are of great interest and have been deeply studied. Furthermore, mathematical and computational models have been rapidly growing over the past few years, permitting researches to run complex scenarios saving time and resources. Usually these models focus on specific features of cell migration, making them only suitable to study restricted phenomena. Methods: Here we present a versatile finite element (FE) cell-scale 3D migration model based on probabilities depending in turn on ECM mechanical properties, chemical, fluid and boundary conditions. Results: With this approach we are able to capture important outcomes of cell migration such as: velocities, trajectories, cell shape and aspect ratio, cell stress or ECM displacements. Conclusions: The modular form of the model will allow us to constantly update and redefine it as advancements are made in clarifying how cellular events take place. 000046913 536__ $$9info:eu-repo/grantAgreement/ES/MINECO/DPI2012-38090-C03-01$$9info:eu-repo/grantAgreement/ES/MINECO/BES-2010-029927-FPI$$9info:eu-repo/grantAgreement/EUR/FP7/ERC2012-StG-306751 000046913 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000046913 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000046913 700__ $$aPolacheck, William J 000046913 700__ $$aKamm, Roger D 000046913 700__ $$0(orcid)0000-0002-9864-7683$$aGarcía-Aznar, José Manuel$$uUniversidad de Zaragoza 000046913 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est. 000046913 773__ $$g1, 2 (2014), [17 pp.]$$tIn Silico Cell and Tissue Science$$x2196-050X 000046913 8564_ $$s2840719$$uhttps://zaguan.unizar.es/record/46913/files/texto_completo.pdf$$yVersión publicada 000046913 8564_ $$s109754$$uhttps://zaguan.unizar.es/record/46913/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000046913 909CO $$ooai:zaguan.unizar.es:46913$$particulos$$pdriver 000046913 951__ $$a2019-09-30-12:51:32 000046913 980__ $$aARTICLE