000046915 001__ 46915
000046915 005__ 20230421130003.0
000046915 0247_ $$2doi$$a10.1007/s40571-014-0006-7
000046915 0248_ $$2sideral$$a91010
000046915 037__ $$aART-2014-91010
000046915 041__ $$aeng
000046915 100__ $$aEscribano, J.
000046915 245__ $$aA discrete approach for modeling cell-matrix adhesions
000046915 260__ $$c2014
000046915 5060_ $$aAccess copy available to the general public$$fUnrestricted
000046915 5203_ $$aDuring recent years the interaction between the extracellular matrix and the cytoskeleton of the cell has been object of numerous studies due to its importance in cell migration processes. These interactions are performed through protein clutches, known as focal adhesions. For migratory cells these focal adhesions along with force gener- ating processes in the cytoskeleton are responsible for the for- mation of protrusion structures like lamellipodia or filopodia. Much is known about these structures: the different proteins that conform them, the players involved in their formation or their role in cell migration. Concretely, growth-cone filopo- dia structures have attracted significant attention because of their role as cell sensors of their surrounding environment and its complex behavior. On this matter, a vast myriad of math- ematical models has been presented to explain its mechan- ical behavior. In this work, we aim to study the mechani- cal behavior of these structures through a discrete approach. This numerical model provides an individual analysis of the proteins involved including spatial distribution, interaction between them, and study of different phenomena, such as clutches unbinding or protein unfolding.
000046915 536__ $$9info:eu-repo/grantAgreement/EUR/FP7/ERC2012-StG-306751$$9info:eu-repo/grantAgreement/ES/MINECO/DPI2012-38090-C03-01
000046915 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000046915 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000046915 700__ $$0(orcid)0000-0002-3514-6443$$aSánchez, M.T.
000046915 700__ $$0(orcid)0000-0002-9864-7683$$aGarcía-Aznar,  J.M.$$uUniversidad de Zaragoza
000046915 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est.
000046915 773__ $$g1, 2 (2014), 117 - 130$$tComputational Particle Mechanics$$x2196-4378
000046915 8564_ $$s3118455$$uhttps://zaguan.unizar.es/record/46915/files/texto_completo.pdf$$yVersión publicada
000046915 8564_ $$s93140$$uhttps://zaguan.unizar.es/record/46915/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000046915 909CO $$ooai:zaguan.unizar.es:46915$$particulos$$pdriver
000046915 951__ $$a2023-04-21-12:37:34
000046915 980__ $$aARTICLE