000046918 001__ 46918
000046918 005__ 20210121114526.0
000046918 0247_ $$2doi$$a10.3892/ol.2015.3572
000046918 0248_ $$2sideral$$a91981
000046918 037__ $$aART-2015-91981
000046918 041__ $$aeng
000046918 100__ $$aCebollero de Miguel, A.
000046918 245__ $$aGene expression profiling and its use in adenocarcinomas of unknown primary origin: A case report
000046918 260__ $$c2015
000046918 5060_ $$aAccess copy available to the general public$$fUnrestricted
000046918 5203_ $$aCarcinomas of unknown primary origin account for 3-5% of all malignancies. The current literature suggests that metastatic dissemination is able to occur in the absence of primary tumor growth. In metastatic disease that is difficult to diagnose, the origin usually remains unknown even after an exhaustive evaluation of immunohistochemistry (IHC) markers. In the current study, a 49-year-old male presented with lymph nodes metastases of unknown origin. The exci- sional biopsy of an inguinal node revealed an adenocarcinoma growth pattern, but the IHC could not determine the primary origin. A gene profiling test was performed to complete the diagnosis and a salivary gland adenocarcinoma was diagnosed with 90% probability. Subsequently, the patient underwent appropriate chemotherapy for salivary gland adenocarcinoma, and exhibited an improved partial response. The present case study highlights the importance of an accurate diagnosis of the primary tumor and the use of all the current tools available in order to provide patients with the best treatment possible
000046918 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000046918 590__ $$a1.482$$b2015
000046918 591__ $$aONCOLOGY$$b181 / 213 = 0.85$$c2015$$dQ4$$eT3
000046918 592__ $$a0.64$$b2015
000046918 593__ $$aOncology$$c2015$$dQ3
000046918 593__ $$aCancer Research$$c2015$$dQ3
000046918 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000046918 700__ $$0(orcid)0000-0002-8026-7391$$aPazo Cid, R.
000046918 700__ $$aMartinez Trufero, J.
000046918 700__ $$aPajares Bernad, I.
000046918 700__ $$aCalera Urquizu, L.
000046918 700__ $$aHernando Cubero, J.
000046918 700__ $$0(orcid)0000-0002-9159-4988$$aAntón Torres, A.$$uUniversidad de Zaragoza
000046918 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000046918 773__ $$g10, 4 (2015), 2657-2661$$pONCOLOGY LETTERS$$tONCOLOGY LETTERS$$x1792-1074
000046918 8564_ $$s333115$$uhttps://zaguan.unizar.es/record/46918/files/texto_completo.pdf$$yVersión publicada
000046918 8564_ $$s120086$$uhttps://zaguan.unizar.es/record/46918/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000046918 909CO $$ooai:zaguan.unizar.es:46918$$particulos$$pdriver
000046918 951__ $$a2021-01-21-11:06:35
000046918 980__ $$aARTICLE