000046975 001__ 46975
000046975 005__ 20200221144126.0
000046975 0247_ $$2doi$$a10.1371/journal.pone.0145929
000046975 0248_ $$2sideral$$a93438
000046975 037__ $$aART-2016-93438
000046975 041__ $$aeng
000046975 100__ $$aMontull, B.
000046975 245__ $$aPredictors of severe sepsis among patients hospitalized for community-acquired pneumonia
000046975 260__ $$c2016
000046975 5060_ $$aAccess copy available to the general public$$fUnrestricted
000046975 5203_ $$aBackground: Severe sepsis, may be present on hospital arrival in approximately one-third of patients with community-acquired pneumonia (CAP). Objective: To determine the host characteristics and micro-organisms associated with severe sepsis in patients hospitalized with CAP. Results: We performed a prospective multicenter cohort study in 13 Spanish hospital, on 4070 hospitalized CAP patients, 1529 of whom (37.6%) presented with severe sepsis. Severe sepsis CAP was independently associated with older age (>65 years), alcohol abuse (OR, 1.31; 95% CI, 1.07-1.61), chronic obstructive pulmonary disease (COPD) (OR, 1.75; 95% CI, 1.50-2.04) and renal disease (OR, 1.57; 95% CI, 1.21-2.03), whereas prior antibiotic treatment was a protective factor (OR, 0.62; 95% CI, 0.52-0.73). Bacteremia (OR, 1.37; 95% CI, 1.05-1.79), S pneumoniae (OR, 1.59; 95% CI, 1.31-1.95) and mixed microbial etiology (OR, 1.65; 95% CI, 1.10-2.49) were associated with severe sepsis CAP. Conclusions: CAP patients with COPD, renal disease and alcohol abuse, as well as those with CAP due to S pneumonia or mixed micro-organisms are more likely to present to the hospital with severe sepsis.
000046975 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000046975 590__ $$a2.806$$b2016
000046975 591__ $$aMULTIDISCIPLINARY SCIENCES$$b15 / 63 = 0.238$$c2016$$dQ1$$eT1
000046975 592__ $$a1.236$$b2016
000046975 593__ $$aAgricultural and Biological Sciences (miscellaneous)$$c2016$$dQ1
000046975 593__ $$aMedicine (miscellaneous)$$c2016$$dQ1
000046975 593__ $$aBiochemistry, Genetics and Molecular Biology (miscellaneous)$$c2016$$dQ1
000046975 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000046975 700__ $$aMenéndez, R.
000046975 700__ $$aTorres, A.
000046975 700__ $$aReyes, S.
000046975 700__ $$aMéndez, R.
000046975 700__ $$aZalacaín, R.
000046975 700__ $$aCapelastegui, A.
000046975 700__ $$aRajas, O.
000046975 700__ $$aBorderías, L.
000046975 700__ $$aMartin-Villasclaras, J.
000046975 700__ $$0(orcid)0000-0003-3670-2664$$aBello, S.$$uUniversidad de Zaragoza
000046975 700__ $$aAlfageme, I.
000046975 700__ $$aDe Castro, F.R.
000046975 700__ $$aRello, J.
000046975 700__ $$aMolinos, L.
000046975 700__ $$aRuiz-Manzano, J.
000046975 700__ $$aAspa, J.
000046975 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000046975 773__ $$g11, 1 (2016), e0145929 [9 pp]$$pPLoS One$$tPloS one$$x1932-6203
000046975 8564_ $$s195304$$uhttps://zaguan.unizar.es/record/46975/files/texto_completo.pdf$$yVersión publicada
000046975 8564_ $$s98790$$uhttps://zaguan.unizar.es/record/46975/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000046975 909CO $$ooai:zaguan.unizar.es:46975$$particulos$$pdriver
000046975 951__ $$a2020-02-21-13:03:41
000046975 980__ $$aARTICLE