47861 20210208180157.0 sideral 91594 doi 10.4321/S0213-61632015000100005 ART-2015-91594 eng (orcid)0000-0002-7277-4318 Moreno, L. Universidad de Zaragoza New perspectives in the search for reliable biomarkers in alzheimer disease 2015 Access copy available to the general public Unrestricted Background and Objectives: The search for accurate biomarkers in Alzheimer Disease (AD), on of the most devastating neurodegenerative diseases, remains essential to enable an early prognosis and diagnosis of the disease and to provide more efficient ther- apeutic strategies. A wide variety of potential biomarkers are has been identified by neuroimaging tech- niques and by the analysis of fluid samples, such as cerebrospinal fluid (CSF) or blood. Recently, a growing number of studies are focused on the discovery of reliable blood- based biomarkers in blood, especially in the prodromal stage of AD, which can predict the conversion of asymptomatic cases to AD demented cases. In this review, the latest challenges in the search for accurate biomarkers of AD is re- vised, in particular, an update in blood-based biomarkers is described in depth. Conclusions: Finally, the close link among AD and other neurodegenerative diseases is discussed, mainly based on the last discovered mutation, the chromosome 9 open reading frame 72, C9ORF72. info:eu-repo/grantAgreement/ES/FIS/PI10-0178 info:eu-repo/semantics/openAccess by-nc-sa http://creativecommons.org/licenses/by-nc-sa/3.0/es/ 0.711 2015 PSYCHIATRY 121 / 139 = 0.871 2015 Q4 T3 0.309 2015 Psychiatry and Mental Health 2015 Q3 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion (orcid)0000-0001-5687-6704 Osta, R. Universidad de Zaragoza (orcid)0000-0001-5193-7782 Calvo, A.C. Universidad de Zaragoza 1001 420 Universidad de Zaragoza Dpto. Anatom.,Embri.Genét.Ani. Área Genética 29, 1 (2015), 51 - 65 Eur. j. psychiatry European Journal of Psychiatry 0213-6163 http://scielo.isciii.es/scielo.php?pid=S0213-61632015000100005&script=sci_abstract Texto completo de la revista 115783 http://zaguan.unizar.es/record/47861/files/texto_completo.pdf Versión publicada 37202 http://zaguan.unizar.es/record/47861/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:47861 articulos driver 2021-02-08-17:41:51 ARTICLE