000048090 001__ 48090
000048090 005__ 20200221144131.0
000048090 0247_ $$2doi$$a10.1186/s13643-015-0181-5
000048090 0248_ $$2sideral$$a93640
000048090 037__ $$aART-2016-93640
000048090 041__ $$aeng
000048090 100__ $$aCatalá-López, F.
000048090 245__ $$aThe quality of reporting methods and results of cost-effectiveness analyses in Spain: A methodological systematic review
000048090 260__ $$c2016
000048090 5060_ $$aAccess copy available to the general public$$fUnrestricted
000048090 5203_ $$aBackground: Cost-effectiveness analysis has been recognized as an important tool to determine the efficiency of healthcare interventions and services. There is a need for evaluating the reporting of methods and results of cost-effectiveness analyses and establishing their validity. We describe and examine reporting characteristics of methods and results of cost-effectiveness analyses conducted in Spain during more than two decades. Methods: A methodological systematic review was conducted with the information obtained through an updated literature review in PubMed and complementary databases (e.g. Scopus, ISI Web of Science, National Health Service Economic Evaluation Database (NHS EED) and Health Technology Assessment (HTA) databases from Centre for Reviews and Dissemination (CRD), Índice Médico Español (IME) Índice Bibliográfico Español en Ciencias de la Salud (IBECS)). We identified cost-effectiveness analyses conducted in Spain that used quality-adjusted life years (QALYs) as outcome measures (period 1989-December 2014). Two reviewers independently extracted the data from each paper. The data were analysed descriptively. Results: In total, 223 studies were included. Very few studies (10; 4.5 %) reported working from a protocol. Most studies (200; 89.7 %) were simulation models and included a median of 1000 patients. Only 105 (47.1 %) studies presented an adequate description of the characteristics of the target population. Most study interventions were categorized as therapeutic (189; 84.8 %) and nearly half (111; 49.8 %) considered an active alternative as the comparator. Effectiveness of data was derived from a single study in 87 (39.0 %) reports, and only few (40; 17.9 %) used evidence synthesis-based estimates. Few studies (42; 18.8 %) reported a full description of methods for QALY calculation. The majority of the studies (147; 65.9 %) reported that the study intervention produced "more costs and more QALYs" than the comparator. Most studies (200; 89.7 %) reported favourable conclusions. Main funding source was the private for-profit sector (135; 60.5 %). Conflicts of interest were not disclosed in 88 (39.5 %) studies. Conclusions: This methodological review reflects that reporting of several important aspects of methods and results are frequently missing in published cost-effectiveness analyses. Without full and transparent reporting of how studies were designed and conducted, it is difficult to assess the validity of study findings and conclusions.
000048090 536__ $$9info:eu-repo/grantAgreement/ES/MICINN/ISCIII-RD12-0001-0004
000048090 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000048090 592__ $$a1.764$$b2016
000048090 593__ $$aMedicine (miscellaneous)$$c2016$$dQ1
000048090 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000048090 700__ $$aRidao, M.
000048090 700__ $$aAlonso-Arroyo, A.
000048090 700__ $$aGarcía-Altés, A.
000048090 700__ $$aCameron, C.
000048090 700__ $$aGonzález-Bermejo, D.
000048090 700__ $$aAleixandre-Benavent, R.
000048090 700__ $$0(orcid)0000-0002-0961-3298$$aBernal-Delgado, E.
000048090 700__ $$aPeiró, S.
000048090 700__ $$aTabarés-Seisdedos, R.
000048090 700__ $$aHutton, B.
000048090 773__ $$g5, 6 (2016), [11 pp.]$$pSyst. rev.$$tSystematic Reviews$$x2046-4053
000048090 8564_ $$s439102$$uhttps://zaguan.unizar.es/record/48090/files/texto_completo.pdf$$yVersión publicada
000048090 8564_ $$s94434$$uhttps://zaguan.unizar.es/record/48090/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000048090 909CO $$ooai:zaguan.unizar.es:48090$$particulos$$pdriver
000048090 951__ $$a2020-02-21-13:04:44
000048090 980__ $$aARTICLE