000048170 001__ 48170
000048170 005__ 20210121114457.0
000048170 0247_ $$2doi$$a10.1371/journal.pone.0121486
000048170 0248_ $$2sideral$$a90772
000048170 037__ $$aART-2015-90772
000048170 041__ $$aeng
000048170 100__ $$0(orcid)0000-0002-6773-6667$$aAriza-Gracia, Miguel A.$$uUniversidad de Zaragoza
000048170 245__ $$aCoupled Biomechanical Response of the Cornea Assessed by Non-Contact Tonometry. A Simulation Study
000048170 260__ $$c2015
000048170 5060_ $$aAccess copy available to the general public$$fUnrestricted
000048170 5203_ $$aThe mechanical response of the cornea subjected to a non-contact air-jet tonometry diagnostic test represents an interplay between its geometry, the corneal material behavior and the loading. The objective is to study this interplay to better understand and interpret the results obtained with a non-contact tonometry test. A patient-specific finite element model of a healthy eye, accounting for the load free configuration, was used. The corneal tissue was modeled as an anisotropic hyperelastic material with two preferential directions. Three different sets of parameters within the human experimental range obtained from inflation tests were considered. The influence of the IOP was studied by considering four pressure levels (10–28 mmHg) whereas the influence of corneal thickness was studied by inducing a uniform variation (300–600 microns). A Computer Fluid Dynamics (CFD) air-jet simulation de- termined pressure loading exerted on the anterior corneal surface. The maximum apex displacement showed a linear variation with IOP for all materials examined. On the contrary, the maximum apex displacement followed a cubic relation with corneal thickness. In addition, a significant sensitivity of the apical displacement to the corneal stiffness was also obtained. Explanation to this behavior was found in the fact that the cornea experiences bending when subjected to an air-puff loading, causing the anterior surface to work in compression whereas the posterior surface works in tension. Hence, collagen fibers located at the anterior surface do not contribute to load bearing. Non-contact tonometry devices give useful information that could be misleading since the corneal deformation is the result of the interaction between the mechanical properties, IOP, and geometry. Therefore, a non- contact tonometry test is not sufficient to evaluate their individual contribution and a complete in-vivo characterization would require more than one test to independently determine the membrane and bending corneal behavior.
000048170 536__ $$9info:eu-repo/grantAgreement/ES/MINECO/DPI2011-27939-C02-01$$9info:eu-repo/grantAgreement/EC/FP7/606634/EU/Development of corneal biomechanical model. Dynamic topographical characterization based on 3D plenoptic imaging/POPCORN
000048170 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000048170 590__ $$a3.057$$b2015
000048170 591__ $$aMULTIDISCIPLINARY SCIENCES$$b11 / 62 = 0.177$$c2015$$dQ1$$eT1
000048170 592__ $$a1.427$$b2015
000048170 593__ $$aAgricultural and Biological Sciences (miscellaneous)$$c2015$$dQ1
000048170 593__ $$aMedicine (miscellaneous)$$c2015$$dQ1
000048170 593__ $$aBiochemistry, Genetics and Molecular Biology (miscellaneous)$$c2015$$dQ1
000048170 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000048170 700__ $$aZurita, Jesus F.
000048170 700__ $$aPiñero, David P.
000048170 700__ $$0(orcid)0000-0001-7612-266X$$aRodriguez Matas, Jose F.$$uUniversidad de Zaragoza
000048170 700__ $$0(orcid)0000-0001-9713-1813$$aCalvo, Begoña$$uUniversidad de Zaragoza
000048170 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est.
000048170 773__ $$g10, 3 (2015), e0121486 [15 p]$$pPLoS One$$tPloS one$$x1932-6203
000048170 8564_ $$s1760013$$uhttps://zaguan.unizar.es/record/48170/files/texto_completo.pdf$$yVersión publicada
000048170 8564_ $$s107948$$uhttps://zaguan.unizar.es/record/48170/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000048170 909CO $$ooai:zaguan.unizar.es:48170$$particulos$$pdriver
000048170 951__ $$a2021-01-21-10:48:59
000048170 980__ $$aARTICLE