000048385 001__ 48385
000048385 005__ 20210121114518.0
000048385 0247_ $$2doi$$a10.1371/journal.pone.0129565
000048385 0248_ $$2sideral$$a91557
000048385 037__ $$aART-2015-91557
000048385 041__ $$aeng
000048385 100__ $$aLorente, L.
000048385 245__ $$aThe 4G/4G genotype of PAI-1 polymorphism is associated with higher plasma PAI-1 concentrations and mortality in patients with severe sepsis
000048385 260__ $$c2015
000048385 5060_ $$aAccess copy available to the general public$$fUnrestricted
000048385 5203_ $$aObjective: Two studies have reported that patients with the 4G/4G genotype of the plasminogen activator inhibitor-1 (PAI-1) genetic polymorphism had higher plasma PAI-1 concentrations and higher risk of death than those with the 4G/5G or 5G/5G genotypes; one study involved 175 children with meningococcal disease, and the other included 88 adult patients with septic shock. Thus, the objective of this study was to determine whether there is an association between carriage of the 4G/4G genotype, plasma PAI-1 concentrations and mortality in a large series of adult septic patients. Methods: An observational, prospective, multicenter study was carried out in six Spanish Intensive Care Units including severe septic patients. We determined the PAI-1 4G/5G polymorphism and plasma PAI-1 concentrations in all patients. The end-points of the study were 30-day and 6-month mortality. Results: We included a total of 260 patients, 82 (31.5%) with 4G/4G, 126 (48.5%) with 4G/5G and 52 (20.0%) with 5G/5G genotype. Multivariate logistic regression analysis showed that the 4G/4G genotype was associated with higher mortality at 30 days (Odds Ratio = 1.95; 95% CI = 1.063-3.561; p = 0.03) and at 6 months (Odds Ratio = 2.19; 95% CI = 1.221-3.934; p = 0.01), and that higher plasma PAI-1 concentrations were associated with higher mortality at 30 days (Odds Ratio = 1.01; 95% CI = 1.002-1.022; p = 0.02) at 6 months (Odds Ratio = 1.01; 95% CI = 1.003-1.023; p = 0.01). Multivariate linear regression analysis showed that increased plasma PAI-1 concentrations were associated with the PAI-1 4G/4G genotype (regression coefficient = 4.82; 95% CI = 3.227 to 6.406; p<0.001). Conclusions: The major findings of our study, to our knowledge the largest series reporting data about 4G/5G polymorphism of the PAI-1 gene, plasma PAI-1 concentrations and mortality in septic patients, were that septic patients with the 4G/4G genotype had higher plasma PAI-1 concentrations and higher risk of death than those with 4G/5G or 5G/5G genotypes.
000048385 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/PI14-00220
000048385 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000048385 590__ $$a3.057$$b2015
000048385 591__ $$aMULTIDISCIPLINARY SCIENCES$$b11 / 62 = 0.177$$c2015$$dQ1$$eT1
000048385 592__ $$a1.427$$b2015
000048385 593__ $$aAgricultural and Biological Sciences (miscellaneous)$$c2015$$dQ1
000048385 593__ $$aMedicine (miscellaneous)$$c2015$$dQ1
000048385 593__ $$aBiochemistry, Genetics and Molecular Biology (miscellaneous)$$c2015$$dQ1
000048385 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000048385 700__ $$aMartín, M.M.
000048385 700__ $$aBorreguero-León, J.M.
000048385 700__ $$aBarrios, Y.
000048385 700__ $$aSolé-Violán, J.
000048385 700__ $$aFerreres, J.
000048385 700__ $$0(orcid)0000-0002-3312-9383$$aLabarta, L.$$uUniversidad de Zaragoza
000048385 700__ $$aDíaz, C.
000048385 700__ $$aJiménez, A.
000048385 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000048385 773__ $$g10, 6 (2015), 0129565 [11 pp]$$pPLoS One$$tPloS one$$x1932-6203
000048385 8564_ $$s464234$$uhttps://zaguan.unizar.es/record/48385/files/texto_completo.pdf$$yVersión publicada
000048385 8564_ $$s98685$$uhttps://zaguan.unizar.es/record/48385/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000048385 909CO $$ooai:zaguan.unizar.es:48385$$particulos$$pdriver
000048385 951__ $$a2021-01-21-11:00:59
000048385 980__ $$aARTICLE