000048408 001__ 48408
000048408 005__ 20170327111930.0
000048408 0247_ $$2doi$$a10.1155/2014/328348
000048408 0248_ $$2sideral$$a94352
000048408 037__ $$aART-2014-94352
000048408 041__ $$aeng
000048408 100__ $$0(orcid)0000-0003-4071-1467$$aLuesma MJ$$uUniversidad de Zaragoza
000048408 245__ $$aNew insights into c-Ret signalling pathway in the enteric nervous system and its relationship with ALS.
000048408 260__ $$c2014
000048408 5060_ $$aAccess copy available to the general public$$fUnrestricted
000048408 5203_ $$aThe receptor tyrosine kinase Ret (c-Ret) transduces the glial cell line-derived neurotrophic factor (GDNF) signal, one of the neurotrophic factors related to the degeneration process or the regeneration activity of motor neurons in amyotrophic lateral sclerosis (ALS). The phosphorylation of several tyrosine residues of c-Ret seems to be altered in ALS. c-Ret is expressed in motor neurons and in the enteric nervous system (ENS) during the embryonic period. The characteristics of the ENS allow using it as model for central nervous system (CNS) study and being potentially useful for the research of human neurological diseases such as ALS. The aim of the present study was to investigate the cellular localization and quantitative evaluation of marker c-Ret in the adult human gut. To assess the nature of c-Ret positive cells, we performed colocalization with specific markers of cells that typically are located in the enteric ganglia. The colocalization of PGP9.5 and c-Ret was preferentially intense in enteric neurons with oval morphology and mostly peripherally localized in the ganglion, so we concluded that the c-Ret receptor is expressed by a specific subtype of enteric neurons in the mature human ENS of the gut. The functional significance of these c-Ret positive neurons is discussed.
000048408 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000048408 590__ $$a1.579$$b2014
000048408 591__ $$aMEDICINE, RESEARCH & EXPERIMENTAL$$b85 / 123 = 0.691$$c2014$$dQ3$$eT3
000048408 591__ $$aBIOTECHNOLOGY & APPLIED MICROBIOLOGY$$b106 / 162 = 0.654$$c2014$$dQ3$$eT2
000048408 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000048408 700__ $$aCantarero I
000048408 700__ $$0(orcid)0000-0002-5106-4843$$aÁlvarez-Dotu JM$$uUniversidad de Zaragoza
000048408 700__ $$0(orcid)0000-0002-1275-2600$$aSantander S$$uUniversidad de Zaragoza
000048408 700__ $$0(orcid)0000-0002-9951-1075$$aJunquera C.$$uUniversidad de Zaragoza
000048408 7102_ $$11004$$2275$$aUniversidad de Zaragoza$$bDepartamento de Cirugía, Ginecología y Obstetricia$$cEstomatología
000048408 7102_ $$11003$$2443$$aUniversidad de Zaragoza$$bDepartamento de Anatomía e Histología Humanas$$cHistología
000048408 7102_ $$11005$$2315$$aUniversidad de Zaragoza$$bDepartamento de Farmacología y Fisiología$$cFarmacología
000048408 7102_ $$11003$$2027$$aUniversidad de Zaragoza$$bDepartamento de Anatomía e Histología Humanas$$cAnatomía y Embriología Humana
000048408 773__ $$g2014 (2014), 328348 [7 p.]$$pBioMed res. int.$$tBioMed Research International$$x2314-6133
000048408 8564_ $$s4261414$$uhttps://zaguan.unizar.es/record/48408/files/texto_completo.pdf$$yVersión publicada
000048408 8564_ $$s100503$$uhttps://zaguan.unizar.es/record/48408/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000048408 909CO $$ooai:zaguan.unizar.es:48408$$particulos$$pdriver
000048408 951__ $$a2016-04-14-11:50:25
000048408 980__ $$aARTICLE