48408 20220120225830.0 doi 10.1155/2014/328348 sideral 94352 ART-2014-94352 eng Luesma MJ Universidad de Zaragoza (orcid)0000-0003-4071-1467 New insights into c-Ret signalling pathway in the enteric nervous system and its relationship with ALS. 2014 Access copy available to the general public Unrestricted The receptor tyrosine kinase Ret (c-Ret) transduces the glial cell line-derived neurotrophic factor (GDNF) signal, one of the neurotrophic factors related to the degeneration process or the regeneration activity of motor neurons in amyotrophic lateral sclerosis (ALS). The phosphorylation of several tyrosine residues of c-Ret seems to be altered in ALS. c-Ret is expressed in motor neurons and in the enteric nervous system (ENS) during the embryonic period. The characteristics of the ENS allow using it as model for central nervous system (CNS) study and being potentially useful for the research of human neurological diseases such as ALS. The aim of the present study was to investigate the cellular localization and quantitative evaluation of marker c-Ret in the adult human gut. To assess the nature of c-Ret positive cells, we performed colocalization with specific markers of cells that typically are located in the enteric ganglia. The colocalization of PGP9.5 and c-Ret was preferentially intense in enteric neurons with oval morphology and mostly peripherally localized in the ganglion, so we concluded that the c-Ret receptor is expressed by a specific subtype of enteric neurons in the mature human ENS of the gut. The functional significance of these c-Ret positive neurons is discussed. info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 1.579 2014 MEDICINE, RESEARCH & EXPERIMENTAL 85 / 123 = 0.691 2014 Q3 T3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY 107 / 163 = 0.656 2014 Q3 T2 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Cantarero I Álvarez-Dotu JM Universidad de Zaragoza (orcid)0000-0002-5106-4843 Santander S Universidad de Zaragoza (orcid)0000-0002-1275-2600 Junquera C. Universidad de Zaragoza (orcid)0000-0002-9951-1075 1004 275 Universidad de Zaragoza Dpto. Cirugía,Ginecol.Obstetr. Área Estomatología 1003 443 Universidad de Zaragoza Dpto. Anatom.Histolog.Humanas Area Histología 1003 027 Universidad de Zaragoza Dpto. Anatom.Histolog.Humanas Area Anatom.Embriol.Humana 1005 315 Universidad de Zaragoza Dpto. Farmacología y Fisiolog. Área Farmacología 2014 (2014), 328348 [7 p.] BioMed res. int. BioMed Research International 2314-6133 4261414 http://zaguan.unizar.es/record/48408/files/texto_completo.pdf Versión publicada 100503 http://zaguan.unizar.es/record/48408/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:48408 articulos driver 2022-01-20-22:53:57 ARTICLE