000048432 001__ 48432 000048432 005__ 20210526094555.0 000048432 0247_ $$2doi$$a10.1186/s12917-016-0692-x 000048432 0248_ $$2sideral$$a93858 000048432 037__ $$aART-2016-93858 000048432 041__ $$aeng 000048432 100__ $$0(orcid)0000-0003-2844-0297$$aArdanaz, Nekane 000048432 245__ $$aInflammatory response to the administration of mesenchymal stem cells in an equine experimental model: effect of autologous, and single and repeat doses of pooled allogeneic cells in healthy joints 000048432 260__ $$c2016 000048432 5060_ $$aAccess copy available to the general public$$fUnrestricted 000048432 5203_ $$aMesenchymal stem cells (MSCs) transplantation has become a promising therapeutic choice for musculoskeletal injuries. Joint-related disorders are highly prevalent in horses. Therefore, these animals are considered as suitable models for testing MSC-based therapies for these diseases. The aim of this study was to investigate the clinical and inflammatory responses to intra-articular single and repeat dose administration of autologous or of pooled allogeneic MSCs in healthy equine healthy joints. Six horses were intra-articularly injected with a single autologous dose of bone marrow derived MSCs (BM-MSCs) and two separate doses of allogeneic BM-MSCs pooled from several donors. All contralateral joints were injected with Lactated Ringer’s Solution (LRS) as the control vehicle. Signs of synovitis and lameness were evaluated at days 0, 1, 2, 3, 5 and 10 after injection. Total protein (TP), white blood cell count (WBC) and neutrophil count (NC) in synovial fluid were also measured at the same time-points. 000048432 536__ $$9info:eu-repo/grantAgreement/ES/MICINN/AGL2011-28609 000048432 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000048432 590__ $$a1.75$$b2016 000048432 591__ $$aVETERINARY SCIENCES$$b24 / 136 = 0.176$$c2016$$dQ1$$eT1 000048432 592__ $$a0.87$$b2016 000048432 593__ $$aVeterinary (miscellaneous)$$c2016$$dQ1 000048432 593__ $$aMedicine (miscellaneous)$$c2016$$dQ2 000048432 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000048432 700__ $$0(orcid)0000-0002-8712-2275$$aVázquez, Francisco José$$uUniversidad de Zaragoza 000048432 700__ $$0(orcid)0000-0001-7188-0461$$aRomero, Antonio$$uUniversidad de Zaragoza 000048432 700__ $$0(orcid)0000-0002-1075-8267$$aRemacha, Ana Rosa$$uUniversidad de Zaragoza 000048432 700__ $$0(orcid)0000-0001-9818-508X$$aBarrachina, Laura$$uUniversidad de Zaragoza 000048432 700__ $$0(orcid)0000-0001-6489-8399$$aSanz, Arianne$$uUniversidad de Zaragoza 000048432 700__ $$0(orcid)0000-0002-4495-8857$$aRanera, Beatriz 000048432 700__ $$0(orcid)0000-0003-1286-4968$$aVitoria, Arantza$$uUniversidad de Zaragoza 000048432 700__ $$0(orcid)0000-0003-4489-3130$$aAlbareda, Jorge$$uUniversidad de Zaragoza 000048432 700__ $$aPrades, Marta 000048432 700__ $$0(orcid)0000-0001-5740-0185$$aZaragoza, Pilar$$uUniversidad de Zaragoza 000048432 700__ $$0(orcid)0000-0001-6016-4726$$aMartín-Burriel, Inmaculada$$uUniversidad de Zaragoza 000048432 700__ $$0(orcid)0000-0003-3289-2675$$aRodellar, Clementina$$uUniversidad de Zaragoza 000048432 7102_ $$11001$$2420$$aUniversidad de Zaragoza$$bDpto. Anatom.,Embri.Genét.Ani.$$cÁrea Genética 000048432 7102_ $$11004$$2830$$aUniversidad de Zaragoza$$bDpto. Cirugía,Ginecol.Obstetr.$$cÁrea Traumatología y Ortopedia 000048432 7102_ $$11009$$2617$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Medicina y Cirugía Animal 000048432 773__ $$g12, 1 (2016), 65 [9 pp.]$$pBMC Vet. Res.$$tBMC VETERINARY RESEARCH$$x1746-6148 000048432 8564_ $$s964277$$uhttps://zaguan.unizar.es/record/48432/files/texto_completo.pdf$$yVersión publicada 000048432 8564_ $$s90054$$uhttps://zaguan.unizar.es/record/48432/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000048432 909CO $$ooai:zaguan.unizar.es:48432$$particulos$$pdriver 000048432 951__ $$a2021-05-26-09:31:04 000048432 980__ $$aARTICLE