48432 20210526094555.0 doi 10.1186/s12917-016-0692-x sideral 93858 ART-2016-93858 eng Ardanaz, Nekane (orcid)0000-0003-2844-0297 Inflammatory response to the administration of mesenchymal stem cells in an equine experimental model: effect of autologous, and single and repeat doses of pooled allogeneic cells in healthy joints 2016 Access copy available to the general public Unrestricted Mesenchymal stem cells (MSCs) transplantation has become a promising therapeutic choice for musculoskeletal injuries. Joint-related disorders are highly prevalent in horses. Therefore, these animals are considered as suitable models for testing MSC-based therapies for these diseases. The aim of this study was to investigate the clinical and inflammatory responses to intra-articular single and repeat dose administration of autologous or of pooled allogeneic MSCs in healthy equine healthy joints. Six horses were intra-articularly injected with a single autologous dose of bone marrow derived MSCs (BM-MSCs) and two separate doses of allogeneic BM-MSCs pooled from several donors. All contralateral joints were injected with Lactated Ringer’s Solution (LRS) as the control vehicle. Signs of synovitis and lameness were evaluated at days 0, 1, 2, 3, 5 and 10 after injection. Total protein (TP), white blood cell count (WBC) and neutrophil count (NC) in synovial fluid were also measured at the same time-points. info:eu-repo/grantAgreement/ES/MICINN/AGL2011-28609 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 1.75 2016 VETERINARY SCIENCES 24 / 136 = 0.176 2016 Q1 T1 0.87 2016 Veterinary (miscellaneous) 2016 Q1 Medicine (miscellaneous) 2016 Q2 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Vázquez, Francisco José Universidad de Zaragoza (orcid)0000-0002-8712-2275 Romero, Antonio Universidad de Zaragoza (orcid)0000-0001-7188-0461 Remacha, Ana Rosa Universidad de Zaragoza (orcid)0000-0002-1075-8267 Barrachina, Laura Universidad de Zaragoza (orcid)0000-0001-9818-508X Sanz, Arianne Universidad de Zaragoza (orcid)0000-0001-6489-8399 Ranera, Beatriz (orcid)0000-0002-4495-8857 Vitoria, Arantza Universidad de Zaragoza (orcid)0000-0003-1286-4968 Albareda, Jorge Universidad de Zaragoza (orcid)0000-0003-4489-3130 Prades, Marta Zaragoza, Pilar Universidad de Zaragoza (orcid)0000-0001-5740-0185 Martín-Burriel, Inmaculada Universidad de Zaragoza (orcid)0000-0001-6016-4726 Rodellar, Clementina Universidad de Zaragoza (orcid)0000-0003-3289-2675 1001 420 Universidad de Zaragoza Dpto. Anatom.,Embri.Genét.Ani. Área Genética 1004 830 Universidad de Zaragoza Dpto. Cirugía,Ginecol.Obstetr. Área Traumatología y Ortopedia 1009 617 Universidad de Zaragoza Dpto. Patología Animal Área Medicina y Cirugía Animal 12, 1 (2016), 65 [9 pp.] BMC Vet. Res. BMC VETERINARY RESEARCH 1746-6148 964277 http://zaguan.unizar.es/record/48432/files/texto_completo.pdf Versión publicada 90054 http://zaguan.unizar.es/record/48432/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:48432 articulos driver 2021-05-26-09:31:04 ARTICLE