000048450 001__ 48450
000048450 005__ 20200221144308.0
000048450 0247_ $$2doi$$a10.1007/s10439-015-1504-3
000048450 0248_ $$2sideral$$a93006
000048450 037__ $$aART-2016-93006
000048450 041__ $$aeng
000048450 100__ $$aChaure, J
000048450 245__ $$aOn studying the interaction between different stent models and rabbit tracheal tissue: numerical, endoscopic and histological comparison
000048450 260__ $$c2016
000048450 5060_ $$aAccess copy available to the general public$$fUnrestricted
000048450 5203_ $$aStenting technique is employed worldwide for treating atherosclerotic vessel and tracheal stenosis. Both diseases can be treated by means of metallic stents which present advantages but are affected by the main problem of restenosis of the stented area. In this study we have built a rabbit trachea numerical model and we have analyzed it before and after insertion and opening of two types of commercial stent: a Zilver® FlexTM Stent and a WallStentTM. In experimental parallel work, two types of stent were implanted in 30 New Zealand rabbits divided in two groups of 10 animals corresponding to each stent type and a third group made up of 10 animals without stent. The tracheal wall response was assessed by means of computerized tomography by endoscopy, macroscopic findings and histopathological study 90 days after stent deployment. Three idealized trachea models, one model for each group, were created in order to perform the computational study. The animal model was used to validate the numerical findings and to attempt to find qualitative correlations between numerical and experimental results. Experimental findings such as inflammation, granuloma and abnormal tissue growth, assessed from histomorphometric analyses were compared with derived numerical parameters such as wall shear stress (WSS) and maximum principal stress. The direct comparison of these parameters and the biological response supports the hypothesis that WSS and tensile stresses may lead to a greater tracheal epithelium response within the stented region, with the latter seeming to have the dominant role. This study may be helpful for improving stent design and demonstrates the feasibility offered by in-silico investigated tracheal structural and fluid dynamics.
000048450 536__ $$9info:eu-repo/grantAgreement/ES/DGA/T88$$9info:eu-repo/grantAgreement/ES/MINECO/DPI2013-44391-P
000048450 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000048450 590__ $$a3.221$$b2016
000048450 591__ $$aENGINEERING, BIOMEDICAL$$b18 / 77 = 0.234$$c2016$$dQ1$$eT1
000048450 592__ $$a1.096$$b2016
000048450 593__ $$aBiomedical Engineering$$c2016$$dQ1
000048450 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000048450 700__ $$0(orcid)0000-0002-8880-6580$$aSerrano, C$$uUniversidad de Zaragoza
000048450 700__ $$0(orcid)0000-0003-2128-9141$$aFernández-Parra, R
000048450 700__ $$0(orcid)0000-0002-0664-5024$$aPeña, E$$uUniversidad de Zaragoza
000048450 700__ $$0(orcid)0000-0002-3158-7022$$aLostalé, F$$uUniversidad de Zaragoza
000048450 700__ $$0(orcid)0000-0002-5618-7519$$aGregorio, MA$$uUniversidad de Zaragoza
000048450 700__ $$0(orcid)0000-0002-8375-0354$$aMartínez, MA$$uUniversidad de Zaragoza
000048450 700__ $$0(orcid)0000-0002-0116-2736$$aMalvè, M
000048450 7102_ $$11010$$2770$$aUniversidad de Zaragoza$$bDpto. Pediatría Radiol.Med.Fís$$cÁrea Radiol. y Medicina Física
000048450 7102_ $$11003$$2443$$aUniversidad de Zaragoza$$bDpto. Anatom.Histolog.Humanas$$cArea Histología
000048450 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est.
000048450 7102_ $$11009$$2617$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Medicina y Cirugía Animal
000048450 773__ $$g44, 2 (2016), 368-381$$pAnn. biomed. eng.$$tANNALS OF BIOMEDICAL ENGINEERING$$x0090-6964
000048450 8564_ $$s659194$$uhttps://zaguan.unizar.es/record/48450/files/texto_completo.pdf$$yPostprint
000048450 8564_ $$s41980$$uhttps://zaguan.unizar.es/record/48450/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000048450 909CO $$ooai:zaguan.unizar.es:48450$$particulos$$pdriver
000048450 951__ $$a2020-02-21-13:35:52
000048450 980__ $$aARTICLE