000048623 001__ 48623
000048623 005__ 20190131090521.0
000048623 0247_ $$2doi$$a10.1109/BIBM.2015.7359887
000048623 0248_ $$2sideral$$a94400
000048623 037__ $$aART-2015-94400
000048623 041__ $$aeng
000048623 100__ $$0(orcid)0000-0003-3852-0987$$aMerino-Casallo, Francisco$$uUniversidad de Zaragoza
000048623 245__ $$aConservation in Mitochondrial DNA: Parallelized Estimation and Alignment Influence
000048623 260__ $$c2015
000048623 5060_ $$aAccess copy available to the general public$$fUnrestricted
000048623 5203_ $$aThe wide availability of sequenced biological data has challenged the conventional methods and tools used in molecular biology to compute the conservation index. As the size of input datasets increases, the time-cost of current conservation methods is becoming unafTordable.
We propose a new software tool that combines several estimation methods applied to the conservation computation process with parallelization and divide-and-conquer techniques substantially improving its performance without affecting its accuracy.
We have also made an in-depth analysis of the impact of different methods and parameter selection on the alignment process applied to input datasets prior to their conservation analysis. We have used sets of mitochondrial DNA sequences with different levels of heterogeneity and length, to provide a full case study.
Both the software tool and the input datasets used in this research are freely available at http://www.zaramit.orglconservation_index
000048623 536__ $$9info:eu-repo/grantAgreement/ES/MINECO/TIN2011-27479-C04-01$$9info:eu-repo/grantAgreement/ES/MEC/FPU-AP2010-1058$$9info:eu-repo/grantAgreement/ES/DGA/T27
000048623 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000048623 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000048623 700__ $$0(orcid)0000-0002-0946-0957$$aÁlvarez-Jarreta, Jorge$$uUniversidad de Zaragoza
000048623 700__ $$0(orcid)0000-0002-9109-5337$$aMayordomo, Elvira$$uUniversidad de Zaragoza
000048623 7102_ $$15007$$2X$$aUniversidad de Zaragoza$$bDpto. Informát.Ingenie.Sistms.$$cProy. investigación HYA
000048623 7102_ $$15007$$2570$$aUniversidad de Zaragoza$$bDpto. Informát.Ingenie.Sistms.$$cÁrea Lenguajes y Sistemas Inf.
000048623 773__ $$g(2015), 1434-1440$$pProceedings (IEEE Int. Conf. Bioinformatics Biomed.)$$tProceedings (IEEE International Conference on Bioinformatics and Biomedicine)$$x2156-1125
000048623 8564_ $$s202066$$uhttps://zaguan.unizar.es/record/48623/files/texto_completo.pdf$$yPostprint
000048623 8564_ $$s132657$$uhttps://zaguan.unizar.es/record/48623/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000048623 909CO $$ooai:zaguan.unizar.es:48623$$particulos$$pdriver
000048623 951__ $$a2019-01-31-08:56:12
000048623 980__ $$aARTICLE