48623 20190131090521.0 doi 10.1109/BIBM.2015.7359887 sideral 94400 ART-2015-94400 eng (orcid)0000-0003-3852-0987 Merino-Casallo, Francisco Universidad de Zaragoza Conservation in Mitochondrial DNA: Parallelized Estimation and Alignment Influence 2015 Access copy available to the general public Unrestricted The wide availability of sequenced biological data has challenged the conventional methods and tools used in molecular biology to compute the conservation index. As the size of input datasets increases, the time-cost of current conservation methods is becoming unafTordable. We propose a new software tool that combines several estimation methods applied to the conservation computation process with parallelization and divide-and-conquer techniques substantially improving its performance without affecting its accuracy. We have also made an in-depth analysis of the impact of different methods and parameter selection on the alignment process applied to input datasets prior to their conservation analysis. We have used sets of mitochondrial DNA sequences with different levels of heterogeneity and length, to provide a full case study. Both the software tool and the input datasets used in this research are freely available at http://www.zaramit.orglconservation_index info:eu-repo/grantAgreement/ES/MINECO/TIN2011-27479-C04-01 info:eu-repo/grantAgreement/ES/MEC/FPU-AP2010-1058 info:eu-repo/grantAgreement/ES/DGA/T27 info:eu-repo/semantics/openAccess All rights reserved http://www.europeana.eu/rights/rr-f/ info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion (orcid)0000-0002-0946-0957 Álvarez-Jarreta, Jorge Universidad de Zaragoza (orcid)0000-0002-9109-5337 Mayordomo, Elvira Universidad de Zaragoza 5007 X Universidad de Zaragoza Dpto. Informát.Ingenie.Sistms. Proy. investigación HYA 5007 570 Universidad de Zaragoza Dpto. Informát.Ingenie.Sistms. Área Lenguajes y Sistemas Inf. (2015), 1434-1440 Proceedings (IEEE Int. Conf. Bioinformatics Biomed.) Proceedings (IEEE International Conference on Bioinformatics and Biomedicine) 2156-1125 202066 http://zaguan.unizar.es/record/48623/files/texto_completo.pdf Postprint 132657 http://zaguan.unizar.es/record/48623/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:48623 articulos driver 2019-01-31-08:56:12 ARTICLE