48626 20210121114457.0 sideral 94556 ART-2015-94556 eng Lorenzo-Tejedor, Mónica Direct infussion Electrospray Mass Spectrometry as a new non-invasive tool for serum metabolomics in induced-stress subjects 2015 Access copy available to the general public Unrestricted Background and Objectives: Nanotechnology is becoming a tool for the study of changes in the metabolome of patients in different states of disease. Analytical techniques such as Electrospray Mass Spectrometry, allow to find biomarkers by determi- nation of metabolites. Nowadays, there is not an objective analytical approach for diagno- sis of stress. Thus, the objectives of this pilot work are: – Describing the development of a fast, direct and non-invasive analytical protocol, ap- plied for the first time, to study the metabolomic profile of patient s different states through a disease. – Testing the protocol in a pilot sample with non-stressed and stress-induced subjects. Methods: High resolution direct infusion electrospray mass spectrometry has been used to analyse the metabolome of blood samples (0.3 ml) from six subject s. Results: Data prove a clear discrimination between non-stressed and stressed states in the metabolome. Data showed different predominant metabolites in both states. Results allow objective characterization of the state of the patient. Conclusions: Although this is a pilot study, the method was successful in discriminating different metabolites in non-stressed and stress-induced subjects. info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 0.711 2015 PSYCHIATRY 121 / 139 = 0.871 2015 Q4 T3 0.309 2015 Psychiatry and Mental Health 2015 Q3 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion (orcid)0000-0003-2284-7862 De la Cámara, Concepción Universidad de Zaragoza (orcid)0000-0002-3360-7015 Lopez-Anton, Raúl Universidad de Zaragoza (orcid)0000-0003-1272-0550 Bailón Luesma, Raquel Universidad de Zaragoza Aguiló, Jordi (orcid)0000-0002-8222-1418 Bernal Ruiz, María Luisa Universidad de Zaragoza 4009 730 Universidad de Zaragoza Dpto. Psicología y Sociología Área Psicología Básica 1005 315 Universidad de Zaragoza Dpto. Farmacología y Fisiolog. Área Farmacología 1007 745 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Psiquiatría 5008 800 Universidad de Zaragoza Dpto. Ingeniería Electrón.Com. Área Teoría Señal y Comunicac. 29, 4 (2015), 259-275 Eur. j. psychiatry European Journal of Psychiatry 0213-6163 604070 http://zaguan.unizar.es/record/48626/files/texto_completo.pdf Versión publicada 48374 http://zaguan.unizar.es/record/48626/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:48626 articulos driver 2021-01-21-10:49:08 ARTICLE