000048658 001__ 48658
000048658 005__ 20200221144247.0
000048658 0247_ $$2doi$$a10.1038/srep23781
000048658 0248_ $$2sideral$$a94739
000048658 037__ $$aART-2016-94739
000048658 041__ $$aeng
000048658 100__ $$aSánchez-Velázquez, P.
000048658 245__ $$aIrreversible electroporation of the liver: Is there a safe limit to the ablation volume?
000048658 260__ $$c2016
000048658 5060_ $$aAccess copy available to the general public$$fUnrestricted
000048658 5203_ $$aIrreversible electroporation is a fast-growing liver ablation technique. Although safety has been well documented in small ablations, our aim is to assess its safety and feasibility when a large portion of liver is ablated. Eighty-seven mice were subjected to high voltage pulses directly delivered across parallel plate electrodes comprising around 40% of mouse liver. One group consisted in 55 athymic-nude, in which a tumor from the KM12C cell line was grown and the other thirty-two C57-Bl6 non-tumoral mice. Both groups were subsequently divided into subsets according to the delivered field strength (1000 V/cm, 2000 V/cm) and whether or not they received anti-hyperkalemia therapy. Early mortality (less than 24 hours post-IRE) in the 2000 V/cm group was observed and revealed considerably higher mean potassium levels. In contrast, the animals subjected to a 2000 V/cm field treated with the anti-hyperkalemia therapy had higher survival rates (OR = 0.1, 95%CI = 0.02-0.32, p < 0.001). Early mortality also depended on the electric field magnitude of the IRE protocol, as mice given 1000 V/cm survived longer than those given 2000 V/cm (OR = 4.7, 95%CI = 1.8-11.8, p = 0.001). Our findings suggest that ionic disturbances, mainly due to potassium alterations, should be warned and envisioned when large volume ablations are performed by IRE.
000048658 536__ $$9info:eu-repo/grantAgreement/ES/MINECO/TEC2010-17285$$9info:eu-repo/grantAgreement/ES/MINECO/TEC2011-27133-C02$$9info:eu-repo/grantAgreement/ES/MINECO/TEC2014-52383-C3-1-R$$9info:eu-repo/grantAgreement/ES/MINECO/TEC2014-52383-C3-2-R$$9info:eu-repo/grantAgreement/ES/MINECO/TEC2014-52383-C3-3-R
000048658 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000048658 590__ $$a4.259$$b2016
000048658 591__ $$aMULTIDISCIPLINARY SCIENCES$$b10 / 63 = 0.159$$c2016$$dQ1$$eT1
000048658 592__ $$a1.691$$b2016
000048658 593__ $$aMultidisciplinary$$c2016$$dQ1
000048658 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000048658 700__ $$aCastellví, Q.
000048658 700__ $$aVillanueva, A.
000048658 700__ $$aQuesada, R.
000048658 700__ $$aPañella, C.
000048658 700__ $$aCáceres, M.
000048658 700__ $$aDorcaratto, D.
000048658 700__ $$aAndaluz, A.
000048658 700__ $$aMoll, X.
000048658 700__ $$aTrujillo, M.
000048658 700__ $$0(orcid)0000-0002-9655-5531$$aBurdió, J.M.$$uUniversidad de Zaragoza
000048658 700__ $$aBerjano, E.
000048658 700__ $$aGrande, L.
000048658 700__ $$aIvorra, A.
000048658 700__ $$aBurdió, F.
000048658 7102_ $$15008$$2785$$aUniversidad de Zaragoza$$bDpto. Ingeniería Electrón.Com.$$cÁrea Tecnología Electrónica
000048658 773__ $$g6 (2016), 23781 [7 pp]$$pSci. rep.$$tSCIENTIFIC REPORTS$$x2045-2322
000048658 8564_ $$s322985$$uhttps://zaguan.unizar.es/record/48658/files/texto_completo.pdf$$yVersión publicada
000048658 8564_ $$s109221$$uhttps://zaguan.unizar.es/record/48658/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000048658 909CO $$ooai:zaguan.unizar.es:48658$$particulos$$pdriver
000048658 951__ $$a2020-02-21-13:25:54
000048658 980__ $$aARTICLE