000048670 001__ 48670
000048670 005__ 20200221144323.0
000048670 0247_ $$2doi$$a10.1186/s12886-016-0216-2
000048670 0248_ $$2sideral$$a94631
000048670 037__ $$aART-2016-94631
000048670 041__ $$aeng
000048670 100__ $$aFerrandez, B.
000048670 245__ $$aAssessment of the retinal nerve fiber layer in individuals with obstructive sleep apnea
000048670 260__ $$c2016
000048670 5060_ $$aAccess copy available to the general public$$fUnrestricted
000048670 5203_ $$aBackground: The effect of obstructive sleep apnea (OSA) syndrome in the peripapillary retinal nerve fiber layer (RNFL) thicknesses remains unclear. The purpose of this study was to assess RNFL measurements acquired using scanning laser polarimetry (SLP) and optical coherence tomography (OCT) in patients with OSA. Methods: The sample of this cross-sectional study included 40 OSA patients and 45 age-matched controls, consecutively and prospectively selected. All participants underwent at least one reliable standard automated perimetry (SAP) test, while RNFL measurements were obtained using the SLP and OCT. The OSA group was divided into 3 sub-groups based on the apnea/hypopnea index (AHI): mild, moderate, or severe OSA. SAP, SLP, and OCT outcomes were compared between the control and OSA groups. The relationship between AHI and RNFL parameters was also evaluated. Results: Age was not different between both groups. Mean deviation of SAP was -0.47 ± 0.9 dB and -1.43 ± 2.3 dB in the control and OSA groups, respectively (p = 0.01). RNFL thickness measured with OCT was similar between groups. OSA patients showed increased nerve fiber indicator (NFI; 20.9 ± 7.9 versus 16.42 ± 7.82; p = 0.01) and decreased superior average (59.74 ± 10.35 versus 63.73 ± 6.58; p = 0.03) obtained with SLP compared with healthy individuals. In the total sample, NFI and AHI were moderately correlated (r = 0.358; p = 0.001). In severe OSA subjects (n = 22), NFI and AHI had a Spearman correlation coefficient of 0.44 (p = 0.04). Conclusion: RNFL thickness measured with OCT did not differ significantly between groups. Severe OSA was related to a reduction of the RNFL thickness assessed by SLP.
000048670 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI11-01239
000048670 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000048670 590__ $$a1.586$$b2016
000048670 591__ $$aOPHTHALMOLOGY$$b38 / 59 = 0.644$$c2016$$dQ3$$eT2
000048670 592__ $$a0.794$$b2016
000048670 593__ $$aOphthalmology$$c2016$$dQ2
000048670 593__ $$aMedicine (miscellaneous)$$c2016$$dQ2
000048670 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000048670 700__ $$0(orcid)0000-0002-2914-2593$$aFerreras, A.$$uUniversidad de Zaragoza
000048670 700__ $$0(orcid)0000-0002-6202-2382$$aCalvo, P.$$uUniversidad de Zaragoza
000048670 700__ $$aAbadia, B.
000048670 700__ $$0(orcid)0000-0001-9096-2294$$aMarin, J.M.$$uUniversidad de Zaragoza
000048670 700__ $$aPajarin, A.B.
000048670 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000048670 7102_ $$11004$$2646$$aUniversidad de Zaragoza$$bDpto. Cirugía,Ginecol.Obstetr.$$cÁrea Oftalmología
000048670 773__ $$g16 (2016), 40 [7 pp.]$$pBMC OPHTHALMOLOGY$$tBMC OPHTHALMOLOGY$$x1471-2415
000048670 8564_ $$s459752$$uhttps://zaguan.unizar.es/record/48670/files/texto_completo.pdf$$yVersión publicada
000048670 8564_ $$s104798$$uhttps://zaguan.unizar.es/record/48670/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000048670 909CO $$ooai:zaguan.unizar.es:48670$$particulos$$pdriver
000048670 951__ $$a2020-02-21-13:42:30
000048670 980__ $$aARTICLE