000048674 001__ 48674
000048674 005__ 20200221144247.0
000048674 0247_ $$2doi$$a10.1039/c5md00515a
000048674 0248_ $$2sideral$$a94727
000048674 037__ $$aART-2016-94727
000048674 041__ $$aeng
000048674 100__ $$aQuintana, M.
000048674 245__ $$aSquaramides with cytotoxic activity against human gastric carcinoma cells HGC-27: Synthesis and mechanism of action
000048674 260__ $$c2016
000048674 5060_ $$aAccess copy available to the general public$$fUnrestricted
000048674 5203_ $$aA series of squaramates and squaramides have been synthesized and their cytotoxic activity has been investigated in different cancer cell lines. Among the studied compounds, squaramide 34 showed a potent and selective cytotoxicity against the human gastric cancer cell line HGC-27. Studies directed to elucidate the mechanism of induced cell death were performed. Cell cycle distribution analysis and cell death studies showed that compound 34 induces cell cycle arrest at the G1 phase and caspase-dependent apoptosis. In conclusion, squaramide 34 can be considered a potential anticancer agent for gastric carcinoma.
000048674 536__ $$9info:eu-repo/grantAgreement/ES/DGA/E104$$9info:eu-repo/grantAgreement/ES/MINECO/CTQ2013-44334-P$$9info:eu-repo/grantAgreement/ES/UZ/JIUZ-2014-CIE-07
000048674 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000048674 590__ $$a2.608$$b2016
000048674 591__ $$aCHEMISTRY, MEDICINAL$$b28 / 60 = 0.467$$c2016$$dQ2$$eT2
000048674 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b153 / 287 = 0.533$$c2016$$dQ3$$eT2
000048674 592__ $$a0.913$$b2016
000048674 593__ $$aPharmaceutical Science$$c2016$$dQ1
000048674 593__ $$aBiochemistry$$c2016$$dQ2
000048674 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000048674 700__ $$aAlegre-Requena, J.
000048674 700__ $$0(orcid)0000-0001-6832-8983$$aMarqués-López, E.$$uUniversidad de Zaragoza
000048674 700__ $$0(orcid)0000-0002-5244-9569$$aHerrera, R.P.$$uUniversidad de Zaragoza
000048674 700__ $$aTriola, G.
000048674 7102_ $$12013$$2765$$aUniversidad de Zaragoza$$bDpto. Química Orgánica$$cÁrea Química Orgánica
000048674 773__ $$g7, 3 (2016), 550-561$$pMedChemComm$$tMEDCHEMCOMM$$x2040-2503
000048674 8564_ $$s953538$$uhttps://zaguan.unizar.es/record/48674/files/texto_completo.pdf$$yVersión publicada
000048674 8564_ $$s116528$$uhttps://zaguan.unizar.es/record/48674/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000048674 909CO $$ooai:zaguan.unizar.es:48674$$particulos$$pdriver
000048674 951__ $$a2020-02-21-13:26:01
000048674 980__ $$aARTICLE