48674 20200221144247.0 doi 10.1039/c5md00515a sideral 94727 ART-2016-94727 eng Quintana, M. Squaramides with cytotoxic activity against human gastric carcinoma cells HGC-27: Synthesis and mechanism of action 2016 Access copy available to the general public Unrestricted A series of squaramates and squaramides have been synthesized and their cytotoxic activity has been investigated in different cancer cell lines. Among the studied compounds, squaramide 34 showed a potent and selective cytotoxicity against the human gastric cancer cell line HGC-27. Studies directed to elucidate the mechanism of induced cell death were performed. Cell cycle distribution analysis and cell death studies showed that compound 34 induces cell cycle arrest at the G1 phase and caspase-dependent apoptosis. In conclusion, squaramide 34 can be considered a potential anticancer agent for gastric carcinoma. info:eu-repo/grantAgreement/ES/DGA/E104 info:eu-repo/grantAgreement/ES/MINECO/CTQ2013-44334-P info:eu-repo/grantAgreement/ES/UZ/JIUZ-2014-CIE-07 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 2.608 2016 CHEMISTRY, MEDICINAL 28 / 60 = 0.467 2016 Q2 T2 BIOCHEMISTRY & MOLECULAR BIOLOGY 153 / 287 = 0.533 2016 Q3 T2 0.913 2016 Pharmaceutical Science 2016 Q1 Biochemistry 2016 Q2 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Alegre-Requena, J. (orcid)0000-0001-6832-8983 Marqués-López, E. Universidad de Zaragoza (orcid)0000-0002-5244-9569 Herrera, R.P. Universidad de Zaragoza Triola, G. 2013 765 Universidad de Zaragoza Dpto. Química Orgánica Área Química Orgánica 7, 3 (2016), 550-561 MedChemComm MEDCHEMCOMM 2040-2503 953538 http://zaguan.unizar.es/record/48674/files/texto_completo.pdf Versión publicada 116528 http://zaguan.unizar.es/record/48674/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:48674 articulos driver 2020-02-21-13:26:01 ARTICLE