000048685 001__ 48685
000048685 005__ 20200221144326.0
000048685 0247_ $$2doi$$a10.1039/c5nr06850a
000048685 0248_ $$2sideral$$a94675
000048685 037__ $$aART-2016-94675
000048685 041__ $$aeng
000048685 100__ $$aLuque-Michel, E.
000048685 245__ $$aA simple approach to obtain hybrid Au-loaded polymeric nanoparticles with a tunable metal load
000048685 260__ $$c2016
000048685 5060_ $$aAccess copy available to the general public$$fUnrestricted
000048685 5203_ $$aA new strategy to nanoengineer multi-functional polymer-metal hybrid nanostructures is reported. By using this protocol the hurdles of most of the current developments concerning covalent and non-covalent attachment of polymers to preformed inorganic nanoparticles (NPs) are overcome. The strategy is based on the in situ reduction of metal precursors using the polymeric nanoparticle as a nanoreactor. Gold nanoparticles and poly(dl-lactic-co-glycolic acid), PLGA, are located in the core and shell, respectively. This novel technique enables the production of PLGA NPs smaller than 200 nm that bear either a single encapsulated Au NP or several smaller NPs with tunable sizes and a 100% loading efficiency. In situ reduction of Au ions inside the polymeric NPs was achieved on demand by using heat to activate the reductive effect of citrate ions. In addition, we show that the loading of the resulting Au NPs inside the PLGA NPs is highly dependent on the surfactant used. Electron microscopy, laser irradiation, UV-Vis and fluorescence spectroscopy characterization techniques confirm the location of Au nanoparticles. These promising results indicate that these hybrid nanomaterials could be used in theranostic applications or as contrast agents in dark-field imaging and computed tomography.
000048685 536__ $$9info:eu-repo/grantAgreement/EC/FP7/614715/EU/A Photo-triggered On-demand Drug Delivery System for Chronic Pain/NANOHEDONISM$$9info:eu-repo/grantAgreement/EC/FP7/321642/EU/Development of a microfluidic platform to produce nanomaterials and assessment on new nanotechnology applications/PLATFORM2NANO$$9info:eu-repo/grantAgreement/EUR/COST/TD1004
000048685 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000048685 590__ $$a7.367$$b2016
000048685 591__ $$aMATERIALS SCIENCE, MULTIDISCIPLINARY$$b23 / 275 = 0.084$$c2016$$dQ1$$eT1
000048685 591__ $$aNANOSCIENCE & NANOTECHNOLOGY$$b13 / 87 = 0.149$$c2016$$dQ1$$eT1
000048685 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b21 / 166 = 0.127$$c2016$$dQ1$$eT1
000048685 591__ $$aPHYSICS, APPLIED$$b13 / 147 = 0.088$$c2016$$dQ1$$eT1
000048685 592__ $$a2.789$$b2016
000048685 593__ $$aNanoscience and Nanotechnology$$c2016$$dQ1
000048685 593__ $$aMaterials Science (miscellaneous)$$c2016$$dQ1
000048685 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000048685 700__ $$0(orcid)0000-0002-6277-7996$$aLarrea, A.$$uUniversidad de Zaragoza
000048685 700__ $$0(orcid)0000-0003-3865-0925$$aLahuerta, C.
000048685 700__ $$0(orcid)0000-0002-6873-5244$$aSebastian, V.$$uUniversidad de Zaragoza
000048685 700__ $$aImbuluzqueta, E.
000048685 700__ $$0(orcid)0000-0003-3165-0156$$aArruebo, M.$$uUniversidad de Zaragoza
000048685 700__ $$aBlanco-Prieto, M.
000048685 700__ $$0(orcid)0000-0002-8701-9745$$aSantamaría, J.$$uUniversidad de Zaragoza
000048685 7102_ $$15005$$2555$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Ingeniería Química
000048685 773__ $$g8, 12 (2016), 6495-6506$$pNanoscale$$tNANOSCALE$$x2040-3364
000048685 8564_ $$s1093810$$uhttps://zaguan.unizar.es/record/48685/files/texto_completo.pdf$$yVersión publicada
000048685 8564_ $$s21800$$uhttps://zaguan.unizar.es/record/48685/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000048685 909CO $$ooai:zaguan.unizar.es:48685$$particulos$$pdriver
000048685 951__ $$a2020-02-21-13:43:57
000048685 980__ $$aARTICLE