48685 20200221144326.0 doi 10.1039/c5nr06850a sideral 94675 ART-2016-94675 eng Luque-Michel, E. A simple approach to obtain hybrid Au-loaded polymeric nanoparticles with a tunable metal load 2016 Access copy available to the general public Unrestricted A new strategy to nanoengineer multi-functional polymer-metal hybrid nanostructures is reported. By using this protocol the hurdles of most of the current developments concerning covalent and non-covalent attachment of polymers to preformed inorganic nanoparticles (NPs) are overcome. The strategy is based on the in situ reduction of metal precursors using the polymeric nanoparticle as a nanoreactor. Gold nanoparticles and poly(dl-lactic-co-glycolic acid), PLGA, are located in the core and shell, respectively. This novel technique enables the production of PLGA NPs smaller than 200 nm that bear either a single encapsulated Au NP or several smaller NPs with tunable sizes and a 100% loading efficiency. In situ reduction of Au ions inside the polymeric NPs was achieved on demand by using heat to activate the reductive effect of citrate ions. In addition, we show that the loading of the resulting Au NPs inside the PLGA NPs is highly dependent on the surfactant used. Electron microscopy, laser irradiation, UV-Vis and fluorescence spectroscopy characterization techniques confirm the location of Au nanoparticles. These promising results indicate that these hybrid nanomaterials could be used in theranostic applications or as contrast agents in dark-field imaging and computed tomography. info:eu-repo/grantAgreement/EC/FP7/614715/EU/A Photo-triggered On-demand Drug Delivery System for Chronic Pain/NANOHEDONISM info:eu-repo/grantAgreement/EC/FP7/321642/EU/Development of a microfluidic platform to produce nanomaterials and assessment on new nanotechnology applications/PLATFORM2NANO info:eu-repo/grantAgreement/EUR/COST/TD1004 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 7.367 2016 MATERIALS SCIENCE, MULTIDISCIPLINARY 23 / 275 = 0.084 2016 Q1 T1 NANOSCIENCE & NANOTECHNOLOGY 13 / 87 = 0.149 2016 Q1 T1 CHEMISTRY, MULTIDISCIPLINARY 21 / 166 = 0.127 2016 Q1 T1 PHYSICS, APPLIED 13 / 147 = 0.088 2016 Q1 T1 2.789 2016 Nanoscience and Nanotechnology 2016 Q1 Materials Science (miscellaneous) 2016 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion (orcid)0000-0002-6277-7996 Larrea, A. Universidad de Zaragoza (orcid)0000-0003-3865-0925 Lahuerta, C. (orcid)0000-0002-6873-5244 Sebastian, V. Universidad de Zaragoza Imbuluzqueta, E. (orcid)0000-0003-3165-0156 Arruebo, M. Universidad de Zaragoza Blanco-Prieto, M. (orcid)0000-0002-8701-9745 Santamaría, J. Universidad de Zaragoza 5005 555 Universidad de Zaragoza Dpto. Ing.Quím.Tecnol.Med.Amb. Área Ingeniería Química 8, 12 (2016), 6495-6506 Nanoscale NANOSCALE 2040-3364 1093810 http://zaguan.unizar.es/record/48685/files/texto_completo.pdf Versión publicada 21800 http://zaguan.unizar.es/record/48685/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:48685 articulos driver 2020-02-21-13:43:57 ARTICLE