000056060 001__ 56060
000056060 005__ 20200221144314.0
000056060 0247_ $$2doi$$a10.3390/molecules21040449
000056060 0248_ $$2sideral$$a94958
000056060 037__ $$aART-2016-94958
000056060 041__ $$aeng
000056060 100__ $$0(orcid)0000-0001-8734-1446$$aFerruz, E.
000056060 245__ $$aEffects of Phenolic Acids on the Growth and Production of T-2 and HT-2 Toxins by Fusarium langsethiae and F. sporotrichioides
000056060 260__ $$c2016
000056060 5060_ $$aAccess copy available to the general public$$fUnrestricted
000056060 5203_ $$aThe effect of natural phenolic acids was tested on the growth and production of T-2 and HT-2 toxins by Fusarium langsethiae and F. sporotrichioides, on Mycotoxin Synthetic medium. Plates treated with 0.5 mM of each phenolic acid (caffeic, chlorogenic, ferulic and p-coumaric) and controls without phenolic acid were incubated for 14 days at 25 °C. Fungal biomass of F. langsethiae and F. sporotrichioides was not reduced by the phenolic acids. However, biosynthesis of T-2 toxin by F. langsethiae was significantly reduced by chlorogenic (23.1%) and ferulic (26.5%) acids. Production of T-2 by F. sporotrichioides also decreased with ferulic acid by 23% (p < 0.05). In contrast, p-coumaric acid significantly stimulated the production of T-2 and HT-2 toxins for both strains. A kinetic study of F. langsethiae with 1 mM ferulic acid showed a significant decrease in fungal biomass, whereas T-2 production increased after 10 days of incubation. The study of gene expression in ferulic supplemented cultures of F. langsethiae revealed a significant inhibition for Tri5, Tri6 and Tri12 genes, while for Tri16 the decrease in gene expression was not statistically significant. Overall, results indicated that phenolic acids had a variable effect on fungal growth and mycotoxin production, depending on the strain and the concentration and type of phenolic acid assayed.
000056060 536__ $$9info:eu-repo/grantAgreement/ES/DGA/A01$$9info:eu-repo/grantAgreement/ES/MINECO-FEDER/AGL 2011-26808$$9info:eu-repo/grantAgreement/ES/MINECO-FEDER/AGL 2014-52648-REDT$$9info:eu-repo/grantAgreement/ES/MINECO-FEDER/AGL 2014-57069-R
000056060 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000056060 590__ $$a2.861$$b2016
000056060 591__ $$aCHEMISTRY, ORGANIC$$b17 / 59 = 0.288$$c2016$$dQ2$$eT1
000056060 592__ $$a0.824$$b2016
000056060 593__ $$aAnalytical Chemistry$$c2016$$dQ1
000056060 593__ $$aPharmaceutical Science$$c2016$$dQ1
000056060 593__ $$aChemistry (miscellaneous)$$c2016$$dQ1
000056060 593__ $$aOrganic Chemistry$$c2016$$dQ2
000056060 593__ $$aPhysical and Theoretical Chemistry$$c2016$$dQ2
000056060 593__ $$aDrug Discovery$$c2016$$dQ2
000056060 593__ $$aMedicine (miscellaneous)$$c2016$$dQ2
000056060 593__ $$aMolecular Medicine$$c2016$$dQ3
000056060 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000056060 700__ $$aAtanasova-Pénichon, V.
000056060 700__ $$aBonnin-Verdal, M.
000056060 700__ $$aMarchegay, G.
000056060 700__ $$aPinson-Gadais, L.
000056060 700__ $$aDucos, C.
000056060 700__ $$0(orcid)0000-0002-1961-8551$$aLorán, S.$$uUniversidad de Zaragoza
000056060 700__ $$0(orcid)0000-0001-6325-7100$$aAriño, A.$$uUniversidad de Zaragoza
000056060 700__ $$aBarreau, C.
000056060 700__ $$aRichard-Forget, F.
000056060 7102_ $$12008$$2640$$aUniversidad de Zaragoza$$bDpto. Produc.Animal Cienc.Ali.$$cÁrea Nutrición Bromatología
000056060 773__ $$g21, 4 (2016), 449 [11 pp]$$pMolecules$$tMolecules$$x1420-3049
000056060 8564_ $$s1142149$$uhttps://zaguan.unizar.es/record/56060/files/texto_completo.pdf$$yVersión publicada
000056060 8564_ $$s105948$$uhttps://zaguan.unizar.es/record/56060/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
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000056060 951__ $$a2020-02-21-13:38:51
000056060 980__ $$aARTICLE